The inhibitory effect of miRNA-1 on ET-1 gene expression

FEBS Letters
Dong LiAn-Jing Ren

Abstract

There is a close correlation between endothelin-1 (ET-1) and microRNA-1 (miRNA-1) expression in the heart, but whether ET-1 expression is regulated by miRNA-1 warrants further research. Our results revealed multiple clues suggesting that miRNA-1 may participate in inhibiting ET-1 gene expression. The inhibitory effect of miRNA-1 on recombinant luciferase reporter gene was mediated by the target sequence at the 127th nucleotide on ET-1 3'UTR. We further confirmed that miRNA-1 could inhibit endogenous ET-1 gene expression at the post-transcriptional level. Our study provides a new perspective on the regulatory mechanism of ET-1 gene.

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Citations

Feb 25, 2014·Cardiovascular Research·Janika ViereckThomas Thum
Mar 19, 2014·Life Sciences·Mollie E JacobsBrian D Cain
Nov 15, 2014·Oncology Reports·Kuo-Wang TsaiHing-Chung Lam
Jan 8, 2017·Journal of Cellular Physiology·Gabriela Placoná DinizMaria Luiza Morais Barreto-Chaves
Jul 26, 2013·Nature Reviews. Cancer·Laura RosanòAnna Bagnato
Sep 2, 2014·Molecular BioSystems·Lian DuanJie Wang
Jun 27, 2020·Gastroenterology Research and Practice·Shuxia TianJunming Chen
May 15, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Gary P Van GuilderRandolph S Faustino

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