The inhibitory effect of selenium nanoparticles on protein glycation in vitro

Nanotechnology
Shaoxuan YuJianlong Wang

Abstract

Selenium nanoparticles (Se NPs) possess well-known excellent biological activities and low toxicity, and have been employed for numerous applications except as inhibitors to protein glycation. Herein, the present study is carried out to investigate the inhibitory effect of Se NPs on protein glycation in a bovine serum albumin (BSA)/glucose system. By measuring the amount of glucose covalently bound onto BSA, the formation of fructosamine and fluorescent products, it is found that Se NPs can hinder the development of protein glycation in a dose-dependent but time-independent manner under the selected reaction conditions (55 °C, 40 h). And after comparing the increase of inhibitory rate in different stages, it is observed that Se NPs show the greatest inhibitory effect in the early stage, then in the advanced stage, but no effect in the intermediate stage. Fourier transform infrared spectroscopy characterization of Se NPs collected after glycation and determination of ·OH influence and glyoxal formation show that the mechanism for the inhibitory efficacy of Se NPs is related to their strong competitive activity against available amino groups in proteins, their great scavenging activity on reactive oxygen species and their inhibit...Continue Reading

References

Mar 1, 1992·Annals of Clinical Biochemistry·C A Le GuenJ Lunec
Dec 31, 1990·Biochemical and Biophysical Research Communications·C J MullarkeyM Brownlee
Jan 1, 1994·Methods in Enzymology·R L LevineE Shacter
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A SmithG Perry
Nov 1, 1996·Bioscience, Biotechnology, and Biochemistry·F HayaseM Yamamoto
Jan 1, 1997·Free Radical Biology & Medicine·S K Jain, M Palmer
Feb 1, 1997·Brain Research. Brain Research Reviews·G MünchP Riederer
May 16, 1998·Biochemical and Biophysical Research Communications·B J OrtwerthM Linetsky
Jul 15, 1999·The International Journal of Biochemistry & Cell Biology·R G Paul, A J Bailey
Sep 14, 1999·Metabolism: Clinical and Experimental·S H IhmJ Ihm
Feb 26, 2000·Journal of Agricultural and Food Chemistry·F YamaguchiH Nakazawa
Feb 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D S RajM Levi
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Mar 29, 2001·Diabetologia·R SinghL Beilin
Jun 2, 2001·Electrophoresis·S E FayleJ M Ames
Jul 19, 2001·Planta medica·H LouS Oka
Apr 4, 2002·Journal of Agricultural and Food Chemistry·Takako NakagawaLekh Raj Juneja
Feb 13, 2003·Journal of Neuropathology and Experimental Neurology·Gary H Danton, W Dalton Dietrich
Mar 6, 2003·Journal of Agricultural and Food Chemistry·Hye Young Kim, Kyong Kim
Oct 30, 2003·Free Radical Biology & Medicine·Bo HuangChang Chen
Dec 20, 2003·American Journal of Nephrology·W Kline BoltonUNKNOWN ACTION I Investigator Group
Jan 28, 2004·Bioscience, Biotechnology, and Biochemistry·Tadashi KihoTakahiro Inakuma
Apr 28, 2004·Parkinsonism & Related Disorders·Patrick L McGeer, Edith G McGeer
Dec 29, 2004·Diabetes Research and Clinical Practice·Nessar Ahmed
Dec 29, 2004·Life Sciences·Jinsong ZhangLide Zhang
Jul 9, 2005·Environmental Health Perspectives·Günter OberdörsterJan Oberdörster
Jul 20, 2005·Current Drug Targets·M C ThomasM E Cooper
Jul 23, 2005·Annals of the New York Academy of Sciences·Ryuichi Wada, Soroku Yagihashi
Aug 30, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S M HussainJ J Schlager
Jun 24, 2006·Drug Discovery Today·V Prakash Reddy, Ayse Beyaz
Jul 21, 2006·The Journal of Physical Chemistry. B·B MishraHari Mohan
Sep 19, 2006·Pathologie-biologie·J Peyroux, M Sternberg
May 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Vicki L Colvin, Kristen M Kulinowski
Aug 4, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Amin Ardestani, Razieh Yazdanparast
Aug 31, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jinsong ZhangTongwen Xu

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Citations

Sep 1, 2020·Journal of Agricultural and Food Chemistry·Peng-Cheng DuYue-Ming Hu

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