PMID: 2964429Dec 1, 1987

The inhibitory effect of sodium alginate on antibiotic activity against mucoid and non-mucoid strains of Pseudomonas aeruginosa

The Journal of Antimicrobial Chemotherapy
R S BaltimoreA S Dobek

Abstract

The exopolysaccharide of mucoid strains of Pseudomonas aeruginosa (MPA) is chemically similar to alginate, a common polysaccharide of seaweeds. Both polymers have been reported to decrease the diameter of the inhibition zones produced in antibiotic disc diffusion assays. In order to determine whether this phenomenon was due to reduced diffusion of the antibiotic in an agar matrix, or to inhibition of antibiotic activity by sodium alginate, we studied the effect of sodium alginate on the susceptibility of P. aeruginosa strains to antibiotics in disc diffusion assays, as well as in broth and agar dilution assays. Sodium alginate decreased the activity of the aminoglycoside antibiotics, amikacin and gentamicin, against two MPA strains and their non-mucoid derivatives in each of the assays. In broth dilution assays, increase of the calcium ion concentration likewise reduced aminoglycoside activity against P. aeruginosa, but not against Escherichia coli and Staphylococcus aureus. Sodium alginate caused no inhibition of the activity of piperacillin and carbenicillin. The reduction of aminoglycoside activity may have implications for the common failure of these antibiotics in the treatment of pulmonary infections caused by MPA in cyst...Continue Reading

Citations

Oct 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A PascualE J Perea
Nov 1, 1991·Antimicrobial Agents and Chemotherapy·N A Hodges, C A Gordon
Jan 17, 2014·Environmental Microbiology·Iain D HayBernd H A Rehm
Apr 11, 2015·Proteins·J L UrbauerRamona J Bieber Urbauer
Apr 22, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Steve W N UengJui-Hsun Weng
Oct 5, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Steve W N UengShih-Jung Liu
Nov 7, 2000·Clinical Orthopaedics and Related Research·S W UengK T Chen

Related Concepts

Xantalgin
mucoid exopolysaccharide (P aeruginosa)
Alginates
Antibiotics
Diffusion
Glycosaminoglycans
Hexuronic Acids
Fungus Drug Sensitivity Tests
Pseudomonas aeruginosa
Glucuronic Acid, 6-(14)C-labeled, (D)-isomer

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

The Journal of Pharmacy and Pharmacology
J D Topham, G P Martin
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Steve W N UengJui-Hsun Weng
Antimicrobial Agents and Chemotherapy
W W NicholsH L Walmsley
© 2021 Meta ULC. All rights reserved