PMID: 2484557Dec 1, 1988Paper

The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase

Biological Trace Element Research
M C ApellaE J Baran

Abstract

The inhibitory effect of vanadate species on the enzymatic activity of bovine copper-zinc superoxide dismutase has been investigated at different pH values and vanadium concentrations. A definite inhibitory effect, clearly related to the main negative charge of each of the vanadate solutions, has been found. The results suggest that the origin of the inhibitory effect may be similar to that found for the phosphate ion, i.e., a diminution of the effectiveness of the substrate electronic guidance mechanism by partial neutralization of the charges close to the active site. Under physiological conditions, the inhibitory effect of vanadate is somewhat smaller than the phosphate.

References

Aug 1, 1985·British Journal of Urology·A S CassC Smith
Apr 24, 1984·Biochemistry·D Mota de Freitas, J S Valentine

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Citations

Jan 1, 1996·Biological Trace Element Research·C M VescinaS B Etcheverry
Mar 1, 1994·Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology·E RussanovS Konstantinova
Jun 7, 2002·Critical Reviews in Oncology/hematology·Angelos M Evangelou
Jan 10, 2019·Current Medicinal Chemistry·Agnieszka Ścibior, Joanna Kurus

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