The Inhibitory Effects of Low-Dose Ionizing Radiation in IgE-Mediated Allergic Responses

PloS One
Hae Mi JooJi Young Kim

Abstract

Ionizing radiation has different biological effects according to dose and dose rate. In particular, the biological effect of low-dose radiation is unclear. Low-dose whole-body gamma irradiation activates immune responses in several ways. However, the effects and mechanism of low-dose radiation on allergic responses remain poorly understood. Previously, we reported that low-dose ionizing radiation inhibits mediator release in IgE-mediated RBL-2H3 mast cell activation. In this study, to have any physiological relevance, we investigated whether low-dose radiation inhibits allergic responses in activated human mast cells (HMC-1(5C6) and LAD2 cells), mouse models of passive cutaneous anaphylaxis and the late-phase cutaneous response. High-dose radiation induced cell death, but low-dose ionizing radiation of <0.5 Gy did not induce mast cell death. Low-dose ionizing radiation that did not induce cell death significantly suppressed mediator release from human mast cells (HMC-1(5C6) and LAD2 cells) that were activated by antigen-antibody reaction. To determine the inhibitory mechanism of mediator released by low-dose ionizing radiation, we examined the phosphorylation of intracellular signaling molecules such as Lyn, Syk, phospholipase ...Continue Reading

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Citations

Jan 21, 2017·Archives of Biochemistry and Biophysics·Heba H MansourShereen M Galal
Dec 31, 2015·International Journal of Immunopathology and Pharmacology·Nan WangLangchong He
May 19, 2018·International Journal of Radiation Biology·Ki Moon SeongYoung Woo Jin
Mar 6, 2019·The Journal of Biological Chemistry·Tatsuya YamazakiSachiko Akashi-Takamura
Jun 23, 2018·Frontiers in Pharmacology·Min-Jong KimSang-Hyun Kim
Dec 5, 2020·Immunopharmacology and Immunotoxicology·Liyan NiuXiaolei Shi
Nov 3, 2020·Frontiers in Genetics·Eunguk ShinBuHyun Youn
Dec 22, 2020·International Journal of Radiation Biology·Yeni Natalia C Perez-GelvezCarl W Bergmann
Nov 19, 2021·Tissue Engineering and Regenerative Medicine·Kyung-Ah ChoSo-Youn Woo

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Methods Mentioned

BETA
ELISA
flow cytometry
PCR
fluorescence microscopy

Software Mentioned

Primer
SAS

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