The inhibitory effects of silver diamine fluoride at different concentrations on matrix metalloproteinases

Dental Materials : Official Publication of the Academy of Dental Materials
May L MeiE C M Lo

Abstract

To study the inhibitory effect of various commercially available concentrations of silver diamine fluoride (SDF) solutions on matrix metalloproteinases (MMPs). Three SDF solutions with concentrations at 38%, 30% and 12% were studied. Two sodium fluoride (NaF) solutions at 10% and 3% were prepared, and they had the same fluoride ion concentrations as 38% and 12% SDF, respectively. Two silver nitrate (AgNO(3)) solutions at 42% and 13% were also prepared, and they had the same silver ion concentrations as 38% and 12% SDF, respectively. Ten samples of each experimental solution were used to study their inhibitory effect on three MMPs, which were MMP-2 (gelatinase A), MMP-8 (neutrophil collagenase) and MMP-9 (gelatinase B) using MMP assay kits. Positive control containing assay buffer at pH 9 and MMPs dilution was used to calculate the percentage inhibition. The percentage inhibition of 38%, 30% and 12% SDF on MMP-2 were 79%, 60% and 17%, respectively (p<0.001); on MMP-8 were 94%, 85% and 77%, respectively (p<0.001); on MMP-9 were 82%, 65% and 60%, respectively (p<0.001). The percentage inhibition on MMP-2, MMP-8 and MMP-9 by 38% SDF was significantly higher than the corresponding percentage inhibition by 10% NaF and 42% AgNO(3). Gr...Continue Reading

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Citations

Feb 28, 2013·Annals of Clinical Microbiology and Antimicrobials·May Lei MeiLakshman Perera Samaranayake
Dec 23, 2015·International Dental Journal·May Lei MeiChun-Hung Chu
Dec 10, 2013·Journal of Dentistry·May L MeiEdward C M Lo
Nov 18, 2014·Frontiers in Physiology·Mayssam KhaddamTchilalo Boukpessi
May 19, 2017·Journal of Dental Research·M L MeiC H Chu
Nov 8, 2013·Journal of Dental Research·M T KatoM A R Buzalaf
Nov 11, 2018·European Journal of Oral Sciences·Pinar AltinciArzu Tezvergil-Mutluay
May 20, 2020·Photobiomodulation, Photomedicine, and Laser Surgery·Kenneth LukChun Hung Chu
Aug 28, 2019·Experimental and Therapeutic Medicine·Ge ZouYan Chen
Aug 29, 2017·Journal of Dental Research·M H T FungC H Chu
Jun 17, 2020·British Dental Journal·Joseph Greenwall-CohenSiobhan Barry
Sep 10, 2020·Brazilian Dental Journal·Fereshteh ShafieiZahra Jowkar
Aug 26, 2020·Restorative Dentistry & Endodontics·Izadora Quintela Souza de MoraesIsabel Cristina Celerino de Moraes Porto
May 26, 2017·International Dental Journal·Irene Shuping ZhaoChun-Hung Chu
May 18, 2018·Journal of Dental Research·M L MeiC H Chu
Jan 26, 2020·British Dental Journal·Nassar SeifoNicola Innes
May 23, 2020·International Journal of Nanomedicine·Iris Xiaoxue YinChun Hung Chu
Dec 2, 2020·Children·Ji-Hye AhnMyeong-Kwan Jih
Mar 4, 2021·International Dental Journal·Gemma BridgeMarta Lomazzi
Jun 2, 2020·Dental Materials : Official Publication of the Academy of Dental Materials·Mahmoud SayedJunji Tagami
Jul 28, 2020·Mycopathologia·Rima Zakzuk AlshahniJunji Tagami
Jul 30, 2021·Journal of Dental Research·R M SulyantoS P Ho

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