The Inhibitory Mechanism of Gentamicin on Electrical Field Stimulation Response in Rat Bladder Smooth Muscle

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Chang Ho MinUy Dong Sohn

Abstract

To see the inhibitory mechanism of gentamicin in response to electrical field stimulation (EFS) using the rat bladder smooth muscle, atropine or guanethidine was treated but had no effect. Methylsergide, a non-selective 5-HT1, 5-HT2 receptor antagonist was also treated but had on effect. Kinase inhibitors, such as chelerythrine (PKC inhibitor), ML-9 (MLCK inhibitor), or Y27632 (rho kinase inhibitor) were pretreated before gentamicin treatment, but did not have effect. For U73122, a phospholipase C (PLC) inhibitor however, the inhibitory effect to gentamicin was significantly attenuated in all frequencies given by the EFS. Therefore gentamicin induced inhibitory effect on EFS response in rat bladder smooth muscle was not mediated by the activation of adrenergic, cholinergic, or serotonergic receptor. The inhibition of gentamicin might be mediated through the PLC dependent pathway, but not through the PKC, MLCK or rho kinase dependent pathway.

References

Mar 1, 1979·Anesthesia and Analgesia·L BurkettF F Foldes
May 1, 1992·Acta Neurologica Scandinavica·I G Milanov
Sep 24, 1991·European Journal of Pharmacology·A TöröcsikE S Vizi
Nov 15, 1990·Biochemical and Biophysical Research Communications·J M HerbertJ P Maffrand
Jan 1, 1972·Annual Review of Pharmacology·C Pittinger, R Adamson
Sep 15, 1971·Annals of the New York Academy of Sciences·E A Wright, M P McQuillen
Jun 1, 1973·Journal of Pharmaceutical Sciences·K O EllisR P Halliday
Aug 1, 1969·British Journal of Urology·J K Todd, A J Mack
Feb 1, 1996·Scandinavian Journal of Urology and Nephrology·K PerssonK E Andersson
Aug 23, 1996·Biochemical and Biophysical Research Communications·H WatanabeR Ohno
Feb 1, 1997·Japanese Journal of Pharmacology·S NiiokaF Hata
Apr 11, 1997·European Journal of Pharmacology·A E Eckly-MichelC Lugnier
May 26, 1999·American Journal of Respiratory Cell and Molecular Biology·A YoshiiM Mori
Dec 22, 1999·Biochemical and Biophysical Research Communications·N KawadaK Kaneda
Nov 28, 2002·Autonomic & Autacoid Pharmacology·R Chess-Williams
Feb 1, 1964·Biochemical Pharmacology·R SANTIA R CONTESSA
Mar 16, 2005·American Journal of Therapeutics·Frank A BeebeStacie Barkin
Sep 20, 2006·Clinical Therapeutics·Thien-Ly DoanPaul F Riska
Nov 29, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Lucas R SmithRichard L Lieber

❮ Previous
Next ❯

Citations

Sep 6, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jong Soo HanUy Dong Sohn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Sun Young ParkUy Dong Sohn
Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
A TedeschiA Miadonna
American Journal of Physiology. Heart and Circulatory Physiology
Geir Øystein AndersenTor Skomedal
© 2021 Meta ULC. All rights reserved