The initial physiological responses to glucose ingestion in normal subjects are modified by a 3 d high-fat diet

The British Journal of Nutrition
M B SideryI A Macdonald

Abstract

The present study was designed to investigate whether 3 d of high-fat, low-carbohydrate diet (with normal daily energy intake) affected the metabolic, cardiovascular and thermic responses to an oral glucose load (1.5 g/kg body-weight). Eight normal weight, healthy subjects (five male) consumed diets containing approximately 65% by energy of carbohydrate (C) or fat (F), each for 3 d. Before and after glucose ingestion, continuous recordings of oxygen consumption and carbon dioxide production were made using indirect calorimetry, and metabolic rate (MR) and respiratory exchange ratio (RER) were calculated. Heart rate, blood pressure and limb blood flow were also measured. There was no significant change in baseline MR following the high-fat diet, but the fasting RER was reduced. The high-fat diet modified the responses to oral glucose, with a greater increase in MR (kJ/min; C + 0.38, F +0.76), and an enhanced plasma insulin response (mU/l; C + 51.5, F + 85.0). There were no differences between the two diets with respect to the baseline blood glucose levels or the changes after glucose ingestion. Heart rate, systolic and diastolic blood pressures and blood flow responses to the glucose load were similar after the two diets. There ...Continue Reading

References

Mar 1, 1978·Neurology·P L CarlenT Steinbach
Oct 1, 1976·Journal of Applied Physiology·E A McGuireM Berman
Jan 1, 1990·The British Journal of Nutrition·I W GallenP I Mansell
May 1, 1989·The American Journal of Clinical Nutrition·H J DaviesA N Howard
Apr 1, 1988·The American Journal of Clinical Nutrition·M Elia, G Livesey
Sep 15, 1986·The American Journal of Cardiology·T C FaganT E Gaffney
Nov 1, 1986·The American Journal of Clinical Nutrition·P Webb
Nov 1, 1985·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·I W Fellows, I A Macdonald
May 1, 1985·Journal of Neuroscience Methods·I A Macdonald, D M Lake
Sep 1, 1983·The Journal of Clinical Investigation·K AchesonJ Wahren
Nov 1, 1984·The Journal of Clinical Investigation·K J AchesonE Jéquier
Nov 1, 1982·Metabolism: Clinical and Experimental·D ThiébaudJ P Felber
Sep 1, 1980·Metabolism: Clinical and Experimental·S WelleR G Campbell
Jul 1, 1953·The Journal of Physiology·R J WHITNEY

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