The Initiation of Th2 Immunity Towards Food Allergens

International Journal of Molecular Sciences
Yosef EllenbogenManel Jordana

Abstract

In contrast with Th1 immune responses against pathogenic viruses and bacteria, the incipient events that generate Th2 responses remain less understood. One difficulty in the identification of universal operating principles stems from the diversity of entities against which cellular and molecular Th2 responses are produced. Such responses are launched against harmful macroscopic parasites and noxious substances, such as venoms, but also against largely innocuous allergens. This suggests that the established understanding about sense and recognition applied to Th1 responses may not be translatable to Th2 responses. This review will discuss processes and signals known to occur in Th2 responses, particularly in the context of food allergy. We propose that perturbations of homeostasis at barrier sites induced by external or internal subverters, which can activate or lower the threshold activation of the immune system, are the major requirement for allergic sensitization. Innate signals produced in the tissue under these conditions equip dendritic cells with a program that forms an adaptive Th2 response.

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Citations

Jun 15, 2020·Allergy·Carmen RiggioniCezmi A Akdis
Jan 15, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Jeffrey F ScottSusan T Nedorost
Mar 16, 2021·The World Allergy Organization Journal·Yuan-Yi ZhangPing-Chang Yang
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Jun 18, 2021·ImmunoTargets and Therapy·Joshua F E KoenigManel Jordana
Apr 27, 2021·International Journal of Women's Dermatology·Susan Nedorost, Margaret Hammond

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Methods Mentioned

BETA
transgenic
glycosylation

Related Concepts