Abstract
Previous studies have shown that during the period subsequent to the Chernobyl accident, increases in morbidity, aggressivity and proliferative activity of renal-cell carcinomas (RCCs) in Ukrainian patients were recognized. The present paper describes the molecular alterations of those tumor suppressor genes located on chromosome 9p21 ( INK4a/ARF locus and p15(INK4B)) in 26 primary renal-cell epithelial tumors from patients with different degrees of radiation exposure after the Chernobyl accident in Ukraine. Radiometric measurement of Cesium 137 ((137)Cs) was conducted with 1-day urine from all patients before surgery. Our results demonstrate that RCCs from patients living in the radio-contaminated areas showed aberrant hypermethylation of p14(ARF) and p16(INK4A) genes, associated with increased p38MAPK, p14(ARF), mdm2, cyclinD1 and Ki67 protein expression levels. Present findings show the possibility that chronic long-term low-dose radiation activates the INK4a/ARF locus, targeted by activation of the p38MAPK cascade. These actions could lead to disruptions and loss of cell cycle checkpoints and, thereby, to cellular transformation.
References
Aug 1, 1991·Health Physics·F RaesG Graziani
Dec 11, 1997·Cell·T KamijoC J Sherr
Jul 11, 1998·The Biochemical Journal·X WangN J Holbrook
Apr 6, 1999·Japanese Journal of Cancer Research : Gann·A RomanenkoS Fukushima
Apr 8, 1999·Molecular Pathology : MP·C E Gillett, D M Barnes
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·L J WuT K Hei
May 20, 1999·Annual Review of Pharmacology and Toxicology·D G Johnson, C L Walker
Sep 24, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A S Lundberg, R A Weinberg
Nov 11, 1999·Oncogene·V AdlerZ Ronai
Feb 19, 2000·Current Opinion in Genetics & Development·C J Sherr, J D Weber
Feb 26, 2000·Carcinogenesis·J B Little
Mar 11, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A S Lundberg, R A Weinberg
Apr 28, 2000·Carcinogenesis·M Serrano
Aug 24, 2000·International Journal of Cancer. Journal International Du Cancer·A RomanenkoA Llombart-Bosch
Mar 10, 2001·Experimental Cell Research·J W Rocco, D Sidransky
Mar 17, 2001·Virchows Archiv : an International Journal of Pathology·A RomanenkoA Llombart-Bosch
Jun 15, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·J A López-GuerreroA Llombart-Bosch
Sep 5, 2001·The EMBO Journal·M D GalibertC R Goding
Citations
Mar 10, 2006·Virchows Archiv : an International Journal of Pathology·Alina RomanenkoAntonio Llombart-Bosch
Oct 7, 2008·The Cancer Journal·Wong-Ho Chow, Susan S Devesa
Feb 19, 2009·Diagnostic Pathology·Vassilis SamarasCalypso Barbatis
Feb 12, 2010·Breast Cancer Research : BCR·Rituparna MukhopadhyayPaul Yaswen
Apr 25, 2007·The Journal of Pathology·Y HoriM Tsuneyoshi
Jan 19, 2006·Genes, Chromosomes & Cancer·Isabella SbranaRoberto Barale
Apr 21, 2006·European Urology·Andriy O YurakhAntonio Llombart-Bosch
Jul 27, 2011·Renal Failure·Viroj Wiwanitkit
May 9, 2016·Pathology Oncology Research : POR·Amparo Ruiz-SauríAntonio Llombart-Bosch
Oct 19, 2016·Molecular BioSystems·Shang LiXia Li
May 15, 2012·Virchows Archiv : an International Journal of Pathology·A M RomanenkoA Llombart-Bosch
Aug 23, 2020·International Journal of Molecular Sciences·Mauro Belli, Maria Antonella Tabocchini
Jan 2, 2021·Frontiers in Public Health·Mauro Belli, Luca Indovina
May 11, 2021·Frontiers in Oncology·Tao ZhangMingjian Lu