The Innate Immune Cross Talk between NK Cells and Eosinophils Is Regulated by the Interaction of Natural Cytotoxicity Receptors with Eosinophil Surface Ligands

Frontiers in Immunology
Silvia PesceE Marcenaro

Abstract

Previous studies suggested that the cross talk between NK cells and other cell types is crucial for the regulation of both innate and adaptive immune responses. In the present study, we analyzed the phenotypic and functional outcome of the interaction between resting or cytokine-activated NK cells and eosinophils derived from non-atopic donors. Our results provide the first evidence that a natural cytotoxicity receptor (NCR)/NCR ligand-dependent cross talk between NK cells and eosinophils may be important to upregulate the activation state and the effector function of cytokine-primed NK cells. This interaction also promotes the NK-mediated editing process of dendritic cells that influence the process of Th1 polarization. In turn, this cross talk also resulted in eosinophil activation and acquisition of the characteristic features of antigen-presenting cells. At higher NK/eosinophil ratios, cytokine-primed NK cells were found to kill eosinophils via NKp46 and NKp30, thus suggesting a potential immunoregulatory role for NK cells in dampening inflammatory responses involving eosinophils.

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Citations

Jan 9, 2018·Oncoimmunology·Gilda VarricchiGiovanna Schiavoni
Sep 8, 2018·American Journal of Respiratory and Critical Care Medicine·Yanaika S Sabogal PiñerosRené Lutter
Sep 10, 2019·Environmental Toxicology·Eun-Jung ParkKyuhong Lee
Mar 22, 2020·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Genny Del ZottoEmanuela Marcenaro
Jul 25, 2018·Current Protocols in Immunology·Roberto Biassoni, Mauro S Malnati
Mar 13, 2020·Frontiers in Cell and Developmental Biology·Silvia PesceEmanuela Marcenaro
Sep 20, 2018·Oncoimmunology·Silvia GaggeroClaudia Cantoni
Feb 14, 2019·Mucosal Immunology·Paola VaccaEmanuela Marcenaro
Sep 10, 2020·Frontiers in Immunology·Claudia CantoniGianluigi Zaza
Dec 2, 2020·Cancers·Silvia PesceEmanuela Marcenaro

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Methods Mentioned

BETA
flow cytometry
density gradient centrifugation
FCS
ELISA

Software Mentioned

CellQuest Pro
GraphPad Prism
PASW Statistic
SPSS Statistics

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