The inner membrane protein, YhiM, is necessary for Escherichia coli (E. coli) survival in acidic conditions

Archives of Microbiology
Tuan M Nguyen, Rebecca L Sparks-Thissen

Abstract

Escherichia coli must be able to survive extreme acidic conditions. We were interested in determining the role of the inner membrane protein YhiM in survival in acidic conditions. Previous data demonstrated that the yhiM gene was upregulated in acidic conditions (Tucker et al. in J Bacteriol. 184:6551-6558, 2002). We therefore tested tn10 insertions into the yhiM gene for their ability to survive at low pH (pH 2.5). We show that YhiM was required for survival at pH 2.5. We also tested the YhiM dependence of the different acid resistance pathways. YhiM was required for the RpoS, glutamine and lysine-dependent acid resistance pathways. In contrast, YhiM was not required for the arginine-dependent acid resistance pathway.

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K KashiwagiK Igarashi
Jul 1, 1987·Molecular & General Genetics : MGG·M Heyde, R Portalier
Jan 1, 1984·Cold Spring Harbor Symposia on Quantitative Biology·T A PattersonA I Bukhari
Jul 1, 1996·Journal of Bacteriology·B M HershJ L Slonczewski
Feb 15, 1997·FEMS Microbiology Letters·S BearsonJ W Foster
May 29, 1999·Journal of Bacteriology·M P Castanie-CornetJ W Foster
Dec 11, 1999·Nucleic Acids Research·K E Rudd
Nov 12, 2002·Journal of Bacteriology·Don L TuckerTyrrell Conway
Nov 5, 2003·Journal of Bacteriology·Ram IyerChristopher Miller
Feb 26, 2004·Molecular Microbiology·Waraporn SoksawatmaekhinKazuei Igarashi
Oct 21, 2004·Nature Reviews. Microbiology·John W Foster
Jul 4, 2009·Advances in Microbial Physiology·Joan L SlonczewskiTerry A Krulwich
Jul 19, 2011·Journal of Bacteriology·Sabrina S AliWilliam Wiley Navarre

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