The inositol phosphatase SHIP controls Salmonella enterica serovar Typhimurium infection in vivo.

Infection and Immunity
Jennifer L BishopB Brett Finlay

Abstract

The SH2 domain-containing inositol 5'-phosphatase, SHIP, negatively regulates various hematopoietic cell functions and is critical for maintaining immune homeostasis. However, whether SHIP plays a role in controlling bacterial infections in vivo remains unknown. Salmonella enterica causes human salmonellosis, a disease that ranges in severity from mild gastroenteritis to severe systemic illness, resulting in significant morbidity and mortality worldwide. The susceptibility of ship(+/+) and ship(-/-) mice and bone marrow-derived macrophages to S. enterica serovar Typhimurium infection was compared. ship(-/-) mice displayed an increased susceptibility to both oral and intraperitoneal serovar Typhimurium infection and had significantly higher bacterial loads in intestinal and systemic sites than ship(+/+) mice, indicating a role for SHIP in the gut-associated and systemic pathogenesis of serovar Typhimurium in vivo. Cytokine analysis of serum from orally infected mice showed that ship(-/-) mice produce lower levels of Th1 cytokines than do ship(+/+) animals at 2 days postinfection, and in vitro analysis of supernatants taken from infected bone marrow-derived macrophages derived to mimic the in vivo ship(-/-) alternatively activate...Continue Reading

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Citations

May 4, 2012·Journal of the Royal Society, Interface·Julia R GogClare E Bryant
Mar 30, 2011·PloS One·Nat F BrownB Brett Finlay
Feb 12, 2009·Molecular Microbiology·Stefan S WeberHubert Hilbi
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Feb 18, 2015·International Immunopharmacology·Shuai-Cheng WuXu-Bin Wei
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Aug 27, 2013·Inflammatory Bowel Diseases·Erin C Steinbach, Scott E Plevy
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Jun 21, 2011·Journal of Leukocyte Biology·Shelley B WeisserLaura M Sly
Sep 1, 2021·Emerging Microbes & Infections·Yuanyuan WangMei Zhang

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