The inotropic effects of UK 14,275, a phosphodiesterase inhibitor, in man

British Journal of Clinical Pharmacology
P G JacksonD Jewitt

Abstract

1. UK 14,275 (Pfizer) an inotropic agent with cardiac phosphodiesterase inhibitory activity, was administered to ten healthy male volunteers. 2. The inotropic activity was assessed by non-invasive measurement of systolic time intervals (STI). 3. The compound had significant inotropic activity in the doses administered, as judged by the shortening of pre-ejection period (PEP), without any significant chronotropic activity. 4. The inotropic effect was abolished when measurements were repeated following beta-adrenoceptor blockade with oral propranolol. 5. The inotropic activity was compared to that of intravenous isoprenaline.

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Related Concepts

Myocardial Contraction
Phosphodiesterase Inhibitors
Human Volunteers
Anticoagulants, Oral
Piperidines
Inotropic agent
Novodrin
Quinazolines
Drug Interactions
Isoproterenol

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