The inotropic effects of UK 14,275, a phosphodiesterase inhibitor, in man

British Journal of Clinical Pharmacology
P G JacksonD Jewitt


1. UK 14,275 (Pfizer) an inotropic agent with cardiac phosphodiesterase inhibitory activity, was administered to ten healthy male volunteers. 2. The inotropic activity was assessed by non-invasive measurement of systolic time intervals (STI). 3. The compound had significant inotropic activity in the doses administered, as judged by the shortening of pre-ejection period (PEP), without any significant chronotropic activity. 4. The inotropic effect was abolished when measurements were repeated following beta-adrenoceptor blockade with oral propranolol. 5. The inotropic activity was compared to that of intravenous isoprenaline.


Jan 1, 1978·British Journal of Clinical Pharmacology·K JenningsD Jewitt
Jan 1, 1990·Cancer Investigation·D V JacksonB L Powell
Feb 1, 1986·The American Journal of Cardiology·S M JafriS Goldstein
Jan 1, 1992·Critical Reviews in Toxicology·P DogteromG K Reznik
Jul 1, 1983·Medicinal Research Reviews·J A Bristol, D B Evans
Jan 1, 1981·Acta Medica Scandinavica. Supplementum·K E Andersson


Jul 1, 1976·Clinical Pharmacology and Therapeutics·F FollathC Dollery
Feb 1, 1969·Circulation Research·G S Levey, S E Epstein
Oct 3, 1974·The New England Journal of Medicine·L I Goldberg
Aug 1, 1971·Circulation·H S LoebR M Gunnar
Jan 1, 1970·The American Journal of the Medical Sciences·A M Weissler, C D Schoenfeld
Apr 1, 1970·The American Journal of Cardiology·C C MetzgerJ J Leonard
Feb 1, 1968·Circulation·A M WeisslerC D Schoenfeld

Related Concepts

Myocardial Contraction
Phosphodiesterase Inhibitors
Human Volunteers
Anticoagulants, Oral
Inotropic agent
Drug Interactions

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