The ins and outs of mitochondrial dysfunction in NASH

Diabetes & Metabolism
B FromentyD Pessayre

Abstract

Rich diet and lack of exercise are causing a surge in obesity, insulin resistance and steatosis, which can evolve into steatohepatitis. Steatosis and nonalcoholic steatohepatitis (NASH) can also be induced by drugs such as amiodarone, tamoxifen and some antiretroviral drugs. There is growing evidence that mitochondrial dysfunction, and more specifically respiratory chain deficiency, plays a role in the pathophysiology of NASH whatever its initial cause. In contrast, the B-oxidation of fatty acids can be either increased (as in insulin resistance-associated NASH) or decreased (as in drug-induced NASH). However, in both circumstances, the generation of reactive oxygen species (ROS) by the damaged respiratory chain is augmented, as components of this chain are over-reduced by electrons, which then abnormally react with oxygen to form increased amounts of ROS. Concomitantly, ROS oxidize fat deposits to release lipid peroxidation products that have detrimental effects on hepatocytes and other hepatic cells. In hepatocytes, ROS and lipid peroxidation products further impair the respiratory chain, either directly or indirectly through oxidative damage to the mitochondrial genome. This, in turn, leads to the generation of more ROS and ...Continue Reading

References

Apr 15, 1991·Biochemical and Biophysical Research Communications·M HayakawaT Ozawa
Jun 1, 1990·Mutation Research·A M Hruszkewycz, D S Bergtold
Sep 1, 1989·Gastroenterology·J C CollinsI Sternlieb
May 31, 1988·Biochemical and Biophysical Research Communications·A M Hruszkewycz
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C RichterB N Ames
Jul 1, 1987·The Journal of Clinical Investigation·K R Feingold, C Grunfeld
Jan 1, 1980·Annual Review of Biochemistry·J D McGarry, D W Foster
Mar 1, 1982·Digestive Diseases and Sciences·J P CapronC Quenum
Jan 1, 1995·Pharmacology & Therapeutics·B Fromenty, D Pessayre
Mar 1, 1995·The Journal of Clinical Investigation·D A AntonettiC R Kahn
Sep 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D De CraemerC Van den Branden
Apr 21, 1995·The Journal of Biological Chemistry·K G PinzD F Bogenhagen
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·M K ShigenagaB N Ames
Apr 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D DeschampsD Pessayre
Jul 1, 1995·Journal of Hepatology·H C PintoM C de Moura
Mar 15, 1996·The Journal of Biological Chemistry·B S KristalB P Yu
Feb 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J G de la AsuncionJ Viña
Jun 1, 1996·Archives of Disease in Childhood·J H Walter
Feb 1, 1996·Journal of Hepatology·P LetteronD Pessayre
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·T M HagenB N Ames
Apr 1, 1997·Journal of Bioenergetics and Biomembranes·E A SchonS DiMauro
Sep 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G LeonarduzziG Poli
Sep 18, 1997·American Journal of Clinical Pathology·B Hu, S W French
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Müller-HöckerB Kadenbach
Nov 21, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M C LinH F Kung
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M D WeltmanC Liddle
Oct 31, 1998·Nature·J M Friedman, J L Halaas

❮ Previous
Next ❯

Citations

Jul 12, 2005·Journal of Gastroenterology·Kazuhiko Koike
Sep 10, 2005·Apoptosis : an International Journal on Programmed Cell Death·A M ElsharkawyD A Mann
Apr 8, 2010·Journal of Bioenergetics and Biomembranes·Ariel R CardosoAlicia J Kowaltowski
Jan 27, 2012·Journal of Physiology and Biochemistry·Mélissa FlammentPierre-Henri Ducluzeau
Jun 21, 2005·Journal of Hepatology·Patrick F Chinnery, Salvatore DiMauro
Jun 9, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Agnieszka Dobrzyn, James M Ntambi
Sep 15, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K Widhalm, E Ghods
Aug 21, 2012·Antioxidants & Redox Signaling·Dolors SerraLaura Herrero
Oct 2, 2009·Journal of Gastroenterology and Hepatology·Hiroshi MurayamaMasaru Hamaoki
May 15, 2012·Journal of Applied Physiology·Ciaran E FealyJohn P Kirwan
Sep 30, 2008·BMC Molecular Biology·Pi-Jung HsiaoShyi-Jang Shin
Jan 20, 2011·Journal of Lipid Research·Amanda J HooperJohn R Burnett
Mar 30, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Leon A AdamsKeith D Lindor
Jan 23, 2009·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Beatrice A Golomb, Marcella A Evans
Nov 22, 2012·Journal of Clinical Biochemistry and Nutrition·Wing PakAkitane Mori
Aug 29, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Katerina BogdanovaJaroslav Vesely
Apr 26, 2014·World Journal of Gastroenterology : WJG·Joanna M LotowskaDariusz M Lebensztejn
Apr 7, 2010·Clinical Lipidology·Sophie C Cazanave, Gregory J Gores
Mar 23, 2010·Hepatology International·Ruth M L De BruyneAnil Dhawan
May 13, 2014·Metabolism: Clinical and Experimental·Fatima AmeerNousheen Zaidi
May 31, 2011·Biochimica Et Biophysica Acta·Jolita CiapaiteJeanine J Prompers
Oct 19, 2004·European Journal of Gastroenterology & Hepatology·Dominique PessayreAbdellah Mansouri
Jul 9, 2005·European Journal of Gastroenterology & Hepatology·Mariana Machado, Helena Cortez-Pinto
Oct 11, 2005·European Journal of Gastroenterology & Hepatology·Arne R J SchneiderJürgen Stein
Aug 22, 2007·Digestive Diseases and Sciences·Zvi AckermanMaria Grozovski
Sep 5, 2009·Digestive Diseases and Sciences·Tamar ShalevHaim Shirin
Jan 18, 2011·Journal of Pediatric Gastroenterology and Nutrition·Christine Carter-KentAriel E Feldstein
Feb 18, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Nicolas Paquot, Jean Delwaide
Dec 13, 2005·FEBS Letters·Marie-Anne RobinBernard Fromenty
Sep 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annamaria ManciniPasqualina Buono
Dec 15, 2015·Expert Review of Clinical Pharmacology·Sherifa A HamedMostafa M Abdellah
Apr 9, 2009·Annals of Medicine·Rafeeq Ali, Kenneth Cusi
Sep 21, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ravirajsinh N JadejaA V Ramachandran
Jul 6, 2010·Life Sciences·Aparajita Dey, Kavitha Swaminathan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Mercedes Pérez-CarrerasJosé A Solis-Herruzo
Journal of Hepatology
D Pessayre, B Fromenty
European Journal of Gastroenterology & Hepatology
D PessayreAbdellah Mansouri
© 2022 Meta ULC. All rights reserved