PMID: 11607650Apr 16, 1996Paper

The insect neuropeptide prothoracicotropic hormone is released with a daily rhythm: re-evaluation of its role in development

Proceedings of the National Academy of Sciences of the United States of America
X Vafopoulou, C G Steel

Abstract

Prothoracicotropic hormone (PTTH) is the central cerebral neurohormone in insect development. Its release has been believed for decades to be confined to one (or two) critical moments early in each developmental stage at which time it triggers prolonged activation of the prothoracic glands to synthesize and release the steroid molting hormones (ecdysteroids), which elicit developmental responses in target tissues. We used an in vitro assay for PTTH released from excised brains of the bug Rhodnius prolixus and report that release of PTTH does occur at the expected time on day 6, but that this release is merely the first in a daily rhythm of release that continues throughout most of the 21 days of larval-adult development. This finding, together with reports of circadian control of ecdysteroid synthesis and titer throughout this time, raises significant challenges to several features of the current understanding of the hormonal control of insect development. New questions are raised concerning the function(s) of PTTH, its relationship with the prothoracic glands, and the significance of circadian rhythmicity throughout this endocrine axis. The significance of the reported observations derives from the set of entirely new question...Continue Reading

References

Apr 1, 1992·General and Comparative Endocrinology·X Vafopoulou, C G Steel
Jan 1, 1993·Insect Biochemistry and Molecular Biology·P Cherbas
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·W E BollenbacherL I Gilbert

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Citations

Dec 16, 2004·Archives of Insect Biochemistry and Physiology·Shi-Hong Gu, Yien-Shing Chow
May 29, 2003·Journal of Insect Physiology·G BlochG E. Robinson
May 29, 2003·Journal of Insect Physiology·J M. Giebultowicz
Apr 13, 2000·Annual Review of Entomology·J M Giebultowicz
Dec 1, 2001·Annual Review of Entomology·Lawrence I GilbertJames T Warren
Nov 15, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Xanthe VafopoulouColin G H Steel
Oct 30, 2010·Journal of Insect Physiology·Vladimír Koštál
May 17, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Colin G H Steel, Xanthe Vafopoulou
Jul 3, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Michael Cardinal-Aucoin, Colin G H Steel
Feb 27, 2001·The Journal of Comparative Neurology·T Siegmund, G Korge
Jul 9, 1999·Archives of Insect Biochemistry and Physiology·X Vafopoulou, C G Steel
May 13, 1999·Journal of Neurogenetics·J C Hall
Oct 11, 2003·Chronobiology International·Edith M Myers
May 31, 2017·Nature Communications·Mareike SelchoJohn Ewer
Oct 9, 2019·Annual Review of Entomology·David S Saunders
Dec 7, 2007·Developmental Cell·Zofeyah McBrayerMichael B O'Connor

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