The insulin-like growth factor I system in cerebellar degeneration

Annals of Neurology
Ignacio Torres-AlemanJ Berciano

Abstract

Brain insulin-like growth factor I (IGF-I) and its related molecules may be involved in neurodegenerative processes in which IGF-I-containing pathways are compromised. Since IGF-I is present in the olivocerebellar circuitry, two types of late-onset cerebellar ataxias (olivopontocerebellar and idiopathic cerebellar cortical atrophy) were chosen to test this hypothesis. The following significant changes in the peripheral IGF-I system of these patients were found: low IGF-I levels, and high IGF-binding protein 1 (BP-1), and BP-3 affinity for IGF-1. Sixty percent of the patients also had significantly low insulin levels. Patients suffering from other neurological diseases with cerebellar dysfunction and ataxia not involving the olivocerebellar pathway also had low IGF-I levels, while IGFBPs and insulin levels were normal. Our data indicate that degeneration of an IGF-I-containing neuronal pathway produces significant changes in the peripheral IGF system. This suggests strongly that the endocrine (bloodborne) and the paracrine/autocrine (brain) IGF systems are linked functionally. We propose that alterations in the blood IGF-I system may constitute a marker of some cerebellar diseases.

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Citations

Sep 6, 2002·Neuroscience Letters·Yoon Hee ChungChoong Ik Cha
Jan 25, 2003·Reviews in the Neurosciences·Jose Luis TrejoIgnacio Torres-Aleman
Nov 28, 2013·Behavioural Brain Research·Daria CameraPhilip Poronnik
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M FernandezI Torres-Aleman
Nov 10, 2001·Brain & Development·R Riikonen
Jun 12, 2012·Endocrinology and Metabolism Clinics of North America·Ignacio Torres Aleman
Oct 27, 2007·Brain Research·Matthias EndresIgnacio Torres-Aleman
Aug 19, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Sharah HosbackPhilip Jakeman
Mar 2, 2011·Proteomics. Clinical Applications·Marzia PerluigiRaffaella Coccia
Apr 21, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Jonas Alex Morales SauteLaura Bannach Jardim
Aug 5, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Maria Teresa PellecchiaPaolo Barone
Jun 14, 2005·Brain Research. Brain Research Reviews·A M FernandezI Torres-Aleman
Oct 3, 2003·Expert Opinion on Pharmacotherapy·Susan L Perlman
Feb 7, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·B R LackeyD M Henricks
Nov 19, 2003·Journal of Biomaterials Applications·C CarrascosaJ J Torrado
Feb 24, 2001·Journal of Child Neurology·R VanhalaP R Riikonen
Sep 29, 2017·International Journal of Molecular Sciences·Raili Riikonen
Jan 1, 2014·Cerebellum & Ataxias·Irene Sanz-GallegoJavier Arpa
Jan 1, 2014·Cerebellum & Ataxias·Irene Sanz-GallegoJavier Arpa

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