The insulin-like growth factor system and cancer

Cancer Letters
D LeRoith, Charles T Roberts

Abstract

The insulin-like growth factor (IGF) family of ligands, binding proteins and receptors is an important growth factor system involved in both the development of the organism and the maintenance of normal function of many cells of the body. The system also has powerful anti-apoptotic effects. More recently, evidence has accrued to demonstrate that the IGFs play an important role in cancer. Individuals with serum IGF-II levels in the upper quartile of the normal range (and IGF binding protein-3 levels in the lower quartiles) have a relative risk for developing breast, prostate, colon and lung cancer. IGF-II is commonly expressed by tumor cells and may act as an autocrine growth factor; occasionally even reaching target tissues and causing tumor-induced hypoglycemia. The IGF-I receptor is commonly (though not always) overexpressed in many cancers, and many recent studies have identified new signaling pathways emanating from the IGF-I receptor that affect cancer cell proliferation, adhesion, migration and cell death; functions that are critical for cancer cell survival and metastases. In this review, many aspects of the IGF system and its relationship to cancer will be discussed.

References

Feb 1, 1994·Current Opinion in Genetics & Development·M F White
Feb 1, 1994·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P CohenR G Rosenfeld
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·H WernerD LeRoith
Jun 24, 1998·Journal of the National Cancer Institute·P Cohen
Jun 24, 1998·Journal of the National Cancer Institute·A WolkD Trichopoulos
Jan 29, 1999·Journal of the National Cancer Institute·H YuX Wu
Nov 23, 2000·Nature·R A DePinho
Dec 5, 2000·International Journal of Cancer. Journal International Du Cancer·B SchnarrD Mayer
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·S SperandioD E Bredesen
Mar 30, 2001·The Journal of Biological Chemistry·S DalleJ M Olefsky
May 15, 2001·International Journal of Cancer. Journal International Du Cancer·A LukanovaR Kaaks
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Katia ScotlandiPiero Picci
Oct 3, 2002·Nature Reviews. Drug Discovery·Pierre De Meyts, Jonathan Whittaker

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Citations

Jan 11, 2005·The Journal of Pathology·E FoulstoneA B Hassan
Mar 31, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Paweł Piątkiewicz, Anna Czech
Jan 15, 2005·International Journal of Colorectal Disease·Rajaraman DuraiMarc C Winslet
Jun 17, 2005·International Journal of Colorectal Disease·M DaviesM Winslet
Aug 12, 2009·International Journal of Colorectal Disease·Kamal YavariMohammad Hossein Babaei
Nov 6, 2004·Breast Cancer Research and Treatment·Gudmundur ThordarsonFrank Talamantes
Nov 4, 2006·Breast Cancer Research and Treatment·Kerstin WagnerAsta Försti
Jun 18, 2009·Cancer Causes & Control : CCC·Anna Carita Callan, Elizabeth Milne
Jun 13, 2012·Cancer Causes & Control : CCC·Dagfinn AuneTeresa Norat
Sep 2, 2006·Journal of Mammary Gland Biology and Neoplasia·Deepali Sachdev, Douglas Yee
Nov 20, 2008·Journal of Mammary Gland Biology and Neoplasia·Antonino Belfiore, Francesco Frasca
Nov 26, 2008·Journal of Mammary Gland Biology and Neoplasia·Deepali Sachdev
Nov 27, 2008·Journal of Mammary Gland Biology and Neoplasia·Quanri Jin, Francisco J Esteva
Feb 16, 2005·Reviews in Endocrine & Metabolic Disorders·Sowmya K Surya, Ariel L Barkan
Apr 29, 2010·Current Diabetes Reports·Emily Jane Gallagher, Derek LeRoith
Jan 5, 2013·Endocrine·Ying-Jian LiuBing-Yin Shi
Dec 25, 2012·Journal of Gastrointestinal Cancer·Sina AlipourWinson Y Cheung
Jun 28, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A González Martín
Mar 6, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lei ZhaoMeng-Zhong Liu
Jun 21, 2005·Biochemical and Biophysical Research Communications·Michio NakamuraAtsushi Ochiai
May 26, 2004·Cancer Letters·Antonella MigliettaClaudia Bocca
May 26, 2004·Critical Reviews in Oncology/hematology·G KleinE S J M de Bont
Sep 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Steven A Rosenzweig
Apr 19, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Alain BeckJean-François Haeuw
Dec 12, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E O ListJ J Kopchick
May 2, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sonja E SteigenTorsten O Nielsen
May 27, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Huamin WangJinsong Liu
Jul 2, 2004·Nature Reviews. Cancer·Michael N PollakSusan E Hankinson
Aug 3, 2004·Nature Reviews. Cancer·Eugenia E Calle, Rudolf Kaaks

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