The insulin-like growth factor system in the prostate

World Journal of Urology
D M PeehlR G Rosenfeld

Abstract

The insulin-like growth factor (IGF) system is involved in the regulation of cell growth. The system involves a network of molecules that includes the IGFs themselves (IGF-I and -II), IGF receptors (types I and II), IGF-binding proteins (IGFBP-1 through -6), and IGFBP proteases. Characterization of this complex system in the prostate has recently been initiated. Prostatic cell lines as well as primary cultures of prostatic epithelial and stromal cells have been analyzed for expression of IGFs, receptors, and IGFBPs. Prostatic epithelial cells and, quite likely, stromal cells as well respond to the mitogenic activity of IGFs via the type I IGF receptor. Prostatic stromal cells synthesize and secrete IGF-II; there is evidence that prostatic cell lines also synthesize IGFs, but this has not been confirmed in primary cultures of prostatic epithelial cells. Prostatic stromal and epithelial cells secrete a number of IGFBPs. The biological impact of some of these IGFBPs on the growth of prostatic cells has been examined, and proteolytic cleavage of IGFBP-3 by prostate-specific antigen (PSA) has been demonstrated. Aberrations in several elements of the IGF system have been observed in stromal cells derived from benign prostatic hyperpl...Continue Reading

Citations

May 13, 2011·Cancer Causes & Control : CCC·Daniel M MoreiraStephen J Freedland
Jun 25, 2005·Journal of Clinical Pathology·C HughesJ O'Leary
May 4, 2011·Differentiation; Research in Biological Diversity·Zongwei Wang, Aria F Olumi
Jun 18, 2010·European Journal of Pharmacology·Ajit VikramPoduri Ramarao
Feb 9, 2000·Radiologic Clinics of North America·S W Hayward, G R Cunha
Dec 22, 2005·American Journal of Physiology. Endocrinology and Metabolism·Hanh LeMarc R Blackman
Nov 13, 2004·American Journal of Physiology. Endocrinology and Metabolism·Julia T ArnoldMarc R Blackman
Nov 19, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Saravana Mohan DhanasekaranArul M Chinnaiyan
Jun 25, 2020·Respiratory Medicine Case Reports·Yutaka TakaharaShiro Mizuno

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