PMID: 11639162Oct 20, 2001Paper

The insulin preparation - Diasulin - that annoyed August Krogh

Dansk medicinhistorisk årbog
R Plum

Abstract

After the two Canadian researchers, Banting and Best, had succeeded in extracting the pancreatic hormone, insulin, from bovine pancreatic tissue in 1921, August and Marie Krogh brought insulin to Denmark on 12 December 1922. With H.C. Hagedorn, who at the time was senior registrar in the III Department of Kobenhavns Kommunehospital (Copenhagen Municipal Hospital), August Krogh immediately began experiments to produce insulin, and already on 21 December, they succeeded in isolating a small amount of insulin from a bovine pancreas. August Kongsted, owner of Lovens Kemiske Fabrik (Leo Chemical Factory), paid the expenses for the experiments and afterwards helped to start the production of >Insulin Leo<. At the start, there was not enough insulin to treat all the diabetics in Denmark, and since Hagedorn was employed in the III Department of Kobenhavns Kommunehospital, this department was the first that had insulin at its disposal. Krogh made it clear that it would probably take several months, maybe even a year, before insulin would be available for all the diabetics in the country. The II Department of Kobenhavn Kommunehospital could not accept this, and as early as May 1923, this department began to treat diabetics with Diasulin ...Continue Reading

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