The insulin receptor and the molecular mechanism of insulin action

Aug 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K Plaschke, S Hoyer

A 180,000 molecular weight glycoprotein substrate of the insulin receptor tyrosine kinase is present in human placenta and in rat liver, muscle, heart and brain plasma membrane preparations

Jan 1, 1990·Cellular Signalling·H J GorenD Boland

In vitro, insulin receptor catalyses phosphorylation of clathrin heavy chain and a plasma membrane 180,000 molecular weight protein

Jan 1, 1991·Cellular Signalling·H J GorenD Boland

Plasma membrane p180, which insulin receptor phosphorylates in vivo, is not a tyrosine kinase

May 1, 1993·Cellular Signalling·H J GorenQ Fei

A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation

May 7, 1991·Journal of Theoretical Biology·M J Quon, L A Campfield

Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats

Nov 20, 2003·Diabetes Research and Clinical Practice·Bolin QinYuzo Sato

Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling

Oct 18, 2001·Molecular and Cellular Endocrinology·V Sánchez-Margalet, S Najib

Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat

Mar 29, 2001·International Journal of Pharmaceutics·M A KiselZ V Zabarovskaya

Cellular insulin action and insulin resistance

Oct 1, 1993·Baillière's Clinical Endocrinology and Metabolism·W T Garvey, M J Birnbaum

Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S NishibeJ J Kim

Activation of phosphatidylinositol 3-kinase by insulin

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N B RudermanL C Cantley

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth

May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P A WildenM F White

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The insulin receptor and the molecular mechanism of insulin action

Abstract

References

Receptor-binding region of insulin.

Regulation of insulin receptors and insulin responsiveness in 3T3-L1 fatty fibroblasts

Receptor binding and biological effect of insulin in human adipocytes

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

An antipeptide antibody that specifically inhibits insulin receptor autophosphorylation and protein kinase activity

Phosphorylation of glycolytic and gluconeogenic enzymes by the insulin receptor kinase

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

Variation in insulin receptor messenger ribonucleic acid expression in human and rodent tissues

Alterations in insulin receptor autophosphorylation in insulin resistance: correlation with altered sensitivity to glucose transport and antilipolysis to insulin

Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance

The insulin receptor gene and its expression in insulin-resistant mice

Defects in human insulin receptor gene expression

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.

The molecular mechanism of insulin action.

The nature and regulation of the insulin receptor: structure and function.

Characterization of insulin receptor carbohydrate by comparison of chemical and enzymatic deglycosylation.

Characterization of phosphatidylinositol kinase activity associated with the insulin receptor.

Insulin receptor kinase and its mode of signaling membrane components.

Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody.

Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid.

Insulin receptor autophosphorylation and kinase activity in streptozotocin diabetic rats. Effect of a short fast.

Defects in insulin binding and autophosphorylation of erythrocyte insulin receptors in patients with syndromes of severe insulin resistance and their parents

Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity

Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity

Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity

Phosphatidylinositol-glycan anchors of membrane proteins: potential precursors of insulin mediators

The glucose transporter in human fibroblasts is phosphorylated in response to phorbol ester but not in response to growth factors

Glucose transport and antilipolysis are differentially regulated by the polar head group of an insulin-sensitive glycophospholipid

Glucocorticoid regulation of insulin receptor gene transcription in IM-9 cultured lymphocytes.

Mechanisms of receptor-mediated transmembrane communication

Characterization of binding and phosphorylation defects of erythrocyte insulin receptors in the type A syndrome of insulin resistance

Studies of the human liver insulin receptor in noninsulin-dependent diabetes mellitus

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity

Phosphorylation of purified insulin receptor by cAMP kinase

Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects

Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells

Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin

Relationship of insulin binding and insulin-stimulated tyrosine kinase activity is altered in type II diabetes

Insulin-activated tyrosine phosphorylation of a 15-kilodalton protein in intact 3T3-L1 adipocytes

Ras p21 as a potential mediator of insulin action in Xenopus oocytes

Substrate specificity and kinetic mechanism of human placental insulin receptor/kinase

Gene for human insulin receptor: localization to site on chromosome 19 involved in pre-B-cell leukemia

Action of insulin modulated by pertussis toxin in rat adipocytes

Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity

Affinity chromatography and purification of the insulin receptor of liver cell membranes

Evidence that the insulin receptor-associated protein kinase acts as a phosphatidylinositol kinase

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta

Citations

Overexpression of membrane glycoprotein PC-1 can influence insulin action at a post-receptor site

Vanadium and diabetes

Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes

Insulin resistance and noninsulin-dependent diabetes mellitus: which horse is pulling the cart?

The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake.

Insulin receptor signaling through non-tyrosine kinase pathways: evidence from anti-receptor antibodies and insulin receptor mutants.

Protein-tyrosine phosphatases and the regulation of insulin action.

Guanine nucleotide binding regulatory proteins in liver from obese humans with and without type II diabetes: evidence for altered "cross-talk" between the insulin receptor and Gi-proteins

Stimulation of protein synthesis by internalized insulin

Insulin induces rapid accumulation of insulin receptors and increases tyrosine kinase activity in the nucleus of cultured adipocytes

Phosphatidylinositol 3-kinase is required for the regulation of hepatitis B surface antigen production and mitogen-activated protein kinase activation by insulin but not by TPA

Robert Feulgen Prize Lecture 1993. The journey of the insulin receptor into the cell: from cellular biology to pathophysiology

The hypophyseal pars tuberalis is enriched with distinct phosphotyrosine-containing proteins not detected in other areas of the brain and pituitary

Excessive glucose production, rather than insulin resistance, accounts for hyperglycaemia in recent-onset streptozotocin-diabetic rats

Insulin resistance in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rat, a new model of NIDDM

Effect of phospholipase treatment on insulin receptor signal transduction

Reproducibility of insulin sensitivity measured by the minimal model method

Chronic primary hyperinsulinaemia is associated with altered insulin receptor mRNA splicing in muscle of patients with insulinoma

Expression of insulin receptor on clonal pancreatic alpha cells and its possible role for insulin-stimulated negative regulation of glucagon secretion

Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease

Insulin resistance in non-insulin-dependent diabetes mellitus. A review

Insulin-like actions of vanadate are mediated in an insulin-receptor-independent manner via non-receptor protein tyrosine kinases and protein phosphotyrosine phosphatases

Effects of calorie restriction and ω-3 dietary fat on aging in short-and long-lived rodents

Phenylarsine oxide and hydrogen peroxide stimulate glucose transport via different pathways in isolated cardiac myocytes

Inhibitory effects of cerulenin on protein palmitoylation and insulin internalization in rat adipocytes

Antipeptide antibodies toward the extracellular domain of insulin receptor beta-subunit