The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice.

Frontiers in Endocrinology
Bo AhrénYutaka Seino

Abstract

A key factor for the insulin response to oral glucose is the pro-glucagon derived incretin hormone glucagon-like peptide-1 (GLP-1), together with the companion incretin hormone, glucose-dependent insulinotropic polypeptide (GIP). Studies in GIP and GLP-1 receptor knockout (KO) mice have been undertaken in several studies to examine this role of the incretin hormones. In the present study, we reviewed the literature on glucose and insulin responses to oral glucose in these mice. We found six publications with such studies reporting results of thirteen separate study arms. The results were not straightforward, since glucose intolerance in GIP or GLP-1 receptor KO mice were reported only in eight of the arms, whereas normal glucose tolerance was reported in five arms. A general potential weakness of the published study is that each of them have examined effects of only one single dose of glucose. In a previous study in mice with genetic deletion of both GLP-1 and GIP receptors we showed that these mice have impaired insulin response to oral glucose after large but not small glucose loads, suggesting that the relevance of the incretin hormones may be dependent on the glucose load. To further test this hypothesis, we have now perfor...Continue Reading

References

Aug 1, 1986·The Journal of Clinical Endocrinology and Metabolism·M A NauckW Creutzfeldt
Jan 1, 1994·Metabolism: Clinical and Experimental·A HvidbergJ J Holst
Jun 1, 1996·The American Journal of Physiology·G Van DijkB Ahrén
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·K MiyawakiY Seino
Jan 24, 2003·American Journal of Physiology. Endocrinology and Metabolism·Nathalie PamirRaymond A Pederson
Mar 23, 2005·Regulatory Peptides·Tanya Hansotia, Daniel J Drucker
Sep 25, 2008·American Journal of Physiology. Endocrinology and Metabolism·Sofianos AndrikopoulosJoseph Proietto
Jan 21, 2012·The Review of Diabetic Studies : RDS·Carolyn F Deacon, Bo Ahrén
May 21, 2013·Cell Metabolism·Jonathan E Campbell, Daniel J Drucker
Jun 14, 2013·Journal of Diabetes Research·G PaciniB Ahrén
Nov 22, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrea TuraBo Ahrén
Apr 29, 2019·Metabolism: Clinical and Experimental·Jens Juul Holst
Feb 6, 2020·Journal of the Endocrine Society·Bo AhrénYutaka Seino
Oct 30, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ram JagannathanMichael Bergman

❮ Previous
Next ❯

Software Mentioned

HOMA
R

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.