The insulin-suppressive effect of resveratrol - an in vitro and in vivo phenomenon

Life Sciences
Tomasz Szkudelski

Abstract

Resveratrol, a naturally occurring phytoalexin, is known to exert numerous beneficial effects in the organism. Literature data indicate that this compound may, among other effects, play a role in prevention of diabetes and diabetic complications. Resveratrol was recently found to affect insulin secretion in vitro and to change blood insulin concentrations. These effects are, however, not fully elucidated. In the present study, 1, 10 and 100microM resveratrol incubated for 90min with pancreatic islets isolated from normal rats failed to affect basal insulin release, but substantially impaired the secretory response to physiological and maximally effective glucose. In depolarized islets exposed to resveratrol, succinate-induced insulin secretion was also diminished. The blockade of somatostatin receptors substantially enhanced insulin secretion induced by 6.7mM glucose and simultaneously suppressed the inhibitory effect of 1microM resveratrol, but at 10 and 100microM, resveratrol was still able to attenuate hormone secretion. Acetylcholine clearly increased the insulin-secretory response to 6.7mM glucose and canceled the inhibitory effect of 1microM resveratrol. However, resveratrol at concentrations 10 and 100microM strongly dec...Continue Reading

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Citations

Apr 2, 2011·Journal of Physiology and Biochemistry·Noemi AriasMaría Puy Portillo
Feb 11, 2011·Oxidative Medicine and Cellular Longevity·Carina Duarte VenturiniClaudia Ramos Rhoden
Sep 9, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Jean-Louis BeaudeuxPhilippe Giral
Apr 14, 2012·Diabetes Research and Clinical Practice·Jiaoyue ZhangXiang Hu
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Sep 21, 2010·Metabolism: Clinical and Experimental·Katarzyna SzkudelskaTomasz Szkudelski
Mar 23, 2010·European Journal of Pharmacology·Katarzyna Szkudelska, Tomasz Szkudelski
May 5, 2009·Life Sciences·Syed M QadriFlorian Lang
Dec 2, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Katarzyna SzkudelskaTomasz Szkudelski
Jun 30, 2009·European Journal of Clinical Investigation·K SzkudelskaT Szkudelski
Jan 26, 2011·Annals of the New York Academy of Sciences·Tomasz Szkudelski, Katarzyna Szkudelska
Aug 19, 2015·Annals of the New York Academy of Sciences·Qinhong XuZhenhua Ma
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Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Naveet Pannu, Archana Bhatnagar

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