The integration of chemotherapy into the management of locally advanced cervical cancer: a pilot study

Gynecologic Oncology
M FriedlanderM H Tattersall


Chemotherapy has been traditionally reserved as a last-time treatment for cervical cancer patients and in this setting long-term remissions are unusual. Platinum-based combination chemotherapy has been associated with high tumor response rates in patients with advanced and metastatic cervical tumors and past experience encouraged evaluation of chemotherapy as a first-line treatment in patients with locally advanced tumors where there is a high likelihood of relapse with local treatment. Thirty patients were treated initially with three courses of cis-platinum, vinblastine, and bleomycin with an overall response rate of 67%, and then had either radiotherapy or surgical resection. The initial results have been encouraging and the integration of chemotherapy into the management of locally advanced cervical cancer warrants further investigation.


Jun 24, 1978·British Medical Journal·P L GoldinerW S Howland
Jan 1, 1973·The British Journal of Radiology·G H Fletcher
Jan 1, 1969·Annual Review of Pharmacology·A C Sartorelli, W A Creasey
Jan 1, 1982·Annals of Internal Medicine·P Stark
Jan 1, 1983·International Journal of Radiation Oncology, Biology, Physics·G S MontanaB B McCafferty
Jul 15, 1981·Cancer·P J DiSaia

❮ Previous
Next ❯


Jul 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P Elliott
Sep 1, 1987·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P F van BommelJ P Neijt
Sep 1, 1986·Clinical Radiology·P R BlakeH E Lambert
Sep 16, 2003·Cancer Treatment Reviews·David H Moore
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·Vicharn LorvidhayaEkachai Visetsiri
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·F LeborgneJ Mezzera
Apr 8, 1998·International Journal of Radiation Oncology, Biology, Physics·P W ShuengH S Liu
Jun 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Benedetti-PaniciS Mancuso
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M. G. EtcheverryA. Nuñez De Pierro
Feb 1, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shuntaro YoshidaKazuhiko Koike
Oct 26, 2000·The Journal of Obstetrics and Gynaecology Research·S J Kim
Nov 16, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Roberto AngioliPierluigi Benedetti-Panici
Aug 31, 2007·Gynecologic Oncology·Pieluigi Benedetti PaniciRoberto Angioli
Dec 1, 1988·Baillière's Clinical Obstetrics and Gynaecology·J SardiN G Rueda
Jun 13, 2006·The Journal of Obstetrics and Gynaecology Research·Hong-Bing CaiHou-Han Yin
Jan 1, 1991·Gynecologic Oncology·P R DottinoC J Cohen
Sep 1, 1990·Gynecologic Oncology·G ThomasB Black
Mar 1, 1987·Gynecologic Oncology·D E BrennerA W Malcolm
May 1, 1991·Gynecologic Oncology·T K ParkJ K Loh
Sep 1, 1988·British Journal of Obstetrics and Gynaecology·P Benedetti PaniciS Mancuso
Mar 18, 1999·Hematology/oncology Clinics of North America·K GrevenR Lanciano
Jun 5, 2003·Expert Opinion on Pharmacotherapy·David H Moore
May 1, 1997·Gynecologic Oncology·E SerurJ C Remy
Aug 19, 2008·Gynecologic Oncology·Pierluigi Benedetti PaniciRoberto Angioli
Jun 1, 1987·British Journal of Obstetrics and Gynaecology·F KirstenM Friedlander
Sep 1, 1990·Gynecologic Oncology·J SardiG di Paola

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.