The Integration of Functional Brain Activity from Adolescence to Adulthood

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Prantik KunduMonique Ernst

Abstract

Age-related changes in human functional neuroanatomy are poorly understood. This is partly due to the limits of interpretation of standard fMRI. These limits relate to age-related variation in noise levels in data from different subjects, and the common use of standard adult brain parcellations for developmental studies. Here we used an emerging MRI approach called multiecho (ME)-fMRI to characterize functional brain changes with age. ME-fMRI acquires blood oxygenation level-dependent (BOLD) signals while also quantifying susceptibility-weighted transverse relaxation time (T2*) signal decay. This approach newly enables reliable detection of BOLD signal components at the subject level as opposed to solely at the group-average level. In turn, it supports more robust characterization of the variability in functional brain organization across individuals. We hypothesized that BOLD components in the resting state are not stable with age, and would decrease in number from adolescence to adulthood. This runs counter to the current assumptions in neurodevelopmental analyses of brain connectivity that the number of BOLD signal components is a random effect. From resting-state ME-fMRI of 51 healthy subjects of both sexes, between 8.3 and...Continue Reading

Citations

Jun 22, 2019·AJNR. American Journal of Neuroradiology·H NawaniE Widjaja
Dec 12, 2019·Journal of the International Neuropsychological Society : JINS·M Alejandra InfanteJoanna Jacobus
Jun 20, 2021·Cerebral Cortex·Lauren KupisLucina Q Uddin
Sep 4, 2021·NeuroImage·Luisa RaimondoWietske van der Zwaag
Sep 4, 2021·Current Opinion in Psychiatry·Andre ZugmanDaniel S Pine

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