The Integration of Metabolomics and Next-Generation Sequencing Data to Elucidate the Pathways of Natural Product Metabolism in Medicinal Plants

Planta medica
Federico ScossaAlisdair R Fernie

Abstract

Plants have always been used as medicines since ancient times to treat diseases. The knowledge around the active components of herbal preparations has remained nevertheless fragmentary: the biosynthetic pathways of many secondary metabolites of pharmacological importance have been clarified only in a few species, while the chemodiversity present in many medicinal plants has remained largely unexplored. Despite the advancements of synthetic biology for production of medicinal compounds in heterologous hosts, the native plant species are often the most reliable and economic source for their production. It thus becomes fundamental to investigate the metabolic composition of medicinal plants to characterize their natural metabolic diversity and to define the biosynthetic routes in planta of important compounds to develop strategies to further increase their content. We present here a number of case studies for selected classes of secondary metabolites and we review their health benefits and the historical developments in their structural elucidation and characterization of biosynthetic genes. We cover the cases of benzoisoquinoline and monoterpenoid indole alkaloids, cannabinoids, caffeine, ginsenosides, withanolides, artemisinin, ...Continue Reading

Citations

Aug 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·Eva KnochKazuki Saito
May 7, 2020·Journal of Basic and Clinical Physiology and Pharmacology·UNKNOWN SutiniWirdhatul Muslihatin
Apr 23, 2020·Frontiers in Pharmacology·Emmanuelle LautiéJean A Boutin
Sep 5, 2020·Trends in Plant Science·Tsubasa Shoji, Ling Yuan
Jan 8, 2021·Frontiers in Bioengineering and Biotechnology·Ahmad Bazli RamziNigel S Scrutton
Feb 22, 2021·The Journal of Biological Chemistry·Anutthaman ParthasarathyAndré O Hudson
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jinjin PengYongjun Wei
Apr 20, 2021·Computational and Structural Biotechnology Journal·Federico Scossa, Alisdair R Fernie
Aug 28, 2021·International Journal of Molecular Sciences·Megha RaiMami Yamazaki
Oct 15, 2021·Natural Product Reports·Roberto G S BerlinckJairo I Quintana-Bulla

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