PMID: 6168369Jul 15, 1981Paper

The integration of new therapies and radiation in the management of ovarian cancer

Cancer
S E OrderD S Ettinger

Abstract

New biologic information has led to a therapeutic program in Stage III ovarian cancer that considers the whole peritoneal cavity the tumor-bearing region and that uses intraperitoneal administration of ovarian cancer antiserum, intraperitoneal P-32, delayed split abdominal irradiation, and chemotherapy. The survival for those patients completing irradiation was 85%. Forty-nine patients with advanced (Stage III, IV, or recurrent) ovarian cancer have been treated with combinations of the present agents. Twenty-two patients have received intraperitoneal ovarian cancer antiserum without significant toxicity. Extensive staging has been a requirement for initial evaluation and includes maximal surgical resection, omentectomy, TAH and BSO, nodal biopsies, and peritoneal cytology. Nineteen patients had 5-mm nodules or less residual disease and were treated with colloidal P-32, abdominal irradiation, and chemotherapy; five of these patients received intraperitoneal antiserum before cytotoxic therapy. The four-year cumulative survival is 84%, and the disease-free survival 43%. A randomized prospective study is now examining the value of antiserum therapy. New experimental data from our laboratory indicate 1) the value of 2/3 biomarkers (...Continue Reading

References

May 1, 1978·International Journal of Radiation Oncology, Biology, Physics·H FlinkS Order
Jun 1, 1979·International Journal of Radiation Oncology, Biology, Physics·S E OrderS A Leibel
Apr 1, 1977·American Journal of Obstetrics and Gynecology·R S BushJ Sturgeon
Oct 26, 1972·The New England Journal of Medicine·C M BagleyV T DeVita
Jul 1, 1974·Cancer·B R ParkerM A Bagshaw
Jun 1, 1980·International Journal of Radiation Oncology, Biology, Physics·S E OrderP Leichner

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Citations

Oct 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J L Pino y TorresS E Order
Jul 1, 1982·International Journal of Radiation Oncology, Biology, Physics·S E Order
Feb 1, 1982·International Journal of Radiation Oncology, Biology, Physics·S E OrderJ Pino Torres
Feb 1, 1983·Journal of Surgical Oncology·E HernandezS E Order

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