PMID: 11467740Jul 27, 2001Paper

The integration of tissue structure and nuclear function

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
C A Maxwell, Michael J Hendzel

Abstract

Living cells can filter the same set of biochemical signals to produce different functional outcomes depending on the deformation of the cell. It has been suggested that the cell may be "hard-wired" such that external forces can mediate internal nuclear changes through the modification of established, balanced, internal cytoskeletal tensions. This review will discuss the potential of subnuclear structures and nuclear chromatin to participate in or respond to transduction of mechanical signals originating outside the nucleus. The mechanical interactions of intranuclear structure with the nuclear lamina will be examined. The nuclear lamina, in turn, provides a structural link between the nucleus and the cytoplasmic and cortical cytoskeleton. These mechanical couplings may provide a basis for regulating gene expression through changes in cell shape.

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Citations

May 9, 2003·The Annals of Thoracic Surgery·Peter WhittakerRobert A Kloner
Apr 20, 2005·Journal of Mammary Gland Biology and Neoplasia·Jordi AlcarazMina J Bissell
Jun 5, 2007·Journal of Cellular Biochemistry·Randall S Gieni, Michael J Hendzel
Jun 19, 2008·Cell Motility and the Cytoskeleton·Mark-Anthony BrayKevin Kit Parker
Apr 28, 2004·Biophysical Journal·Sameer B ShahRichard L Lieber
Apr 22, 2003·Journal of Cellular Physiology·Rohan Samarakoon, Paul J Higgins

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