The integrative physiology of the bladder.

Annals of the Royal College of Surgeons of England
M J Drake

Abstract

Normal bladder function is complex, resulting from the co-operative interaction of numerous regulatory cell types, of which the interstitial cells and the peripheral neurones are particularly interesting. Collectively, these comprise the myovesical plexus, which appears to confer structural and functional characteristics on the bladder loosely akin to those of the gut. These include functional modularity, which gives rise to the potential for localised and propagating peristalsis-like movements in the bladder wall according to the prevailing physiological conditions. Localised modular activity during filling may contribute to normal generation of sensation and exaggerated modular activity may give rise to urinary urgency. Enhanced co-ordination of modular activity occurs in various models of detrusor overactivity; it leads to surges of contraction over a large part of the bladder wall, generating phasic changes in intravesical pressure. During voiding, the myovesical plexus sustains detrusor contraction at the behest of the brainstem, monitoring state of bladder fullness as it does so, as a guide to the required duration for which it has to keep up the effort. Accordingly, the bladder wall itself may house structures which rend...Continue Reading

References

Jan 1, 1993·Neurourology and Urodynamics·B L CoolsaetH V De Bakker
Oct 25, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·M J DrakeA F Brading
Jul 20, 2002·The Journal of Urology·Karen D McCloskey, Alison M Gurney
Jan 15, 2003·Experimental Physiology·M J DrakeJ I Gillespie
Apr 18, 2003·BJU International·M J DrakeA F Brading
Jun 11, 2003·The Journal of Urology·Marcus J DrakeJames I Gillespie
Apr 21, 2005·BJU International·Marcus J DrakeWim A Van Duyl
Jan 13, 2006·The Journal of Urology·Magdalini LagouMarcus J Drake
Feb 14, 2006·BJU International·Suzanne M BiersAlison F Brading
May 12, 2006·BJU International·Magdalini LagouMarcus J Drake
Aug 24, 2006·BJU International·Magdalini LagouJames I Gillespie

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Citations

Jul 9, 2014·Nature Reviews. Urology·Marcus J DrakeDominika A Bijos
Dec 3, 2014·Computers in Biology and Medicine·Di LiuFeng Pan
Dec 19, 2013·Nephro-urology Monthly·Mohammad Sajjad Rahnama'iPhilip E Van Kerrebroeck
Jul 28, 2013·Expert Opinion on Emerging Drugs·Eu Kiang Sharon YeoPaul Abrams
Apr 20, 2010·Maturitas·Emily Henderson, Marcus Drake
Mar 27, 2015·BJU International·Roger G LentleJohn Paul Chambers
Jul 8, 2008·European Urology·Christian Gratzke, Michael Seitz
Nov 9, 2010·Neurourology and Urodynamics·M S LewisP Maruff
Jun 11, 2011·Neurourology and Urodynamics·G A van KoeveringeM Oelke
Feb 11, 2015·Biogerontology·Richard N Ranson, M Jill Saffrey
Jul 27, 2011·Therapeutic Advances in Urology·Richard Foon, Marcus J Drake
Feb 14, 2018·Expert Opinion on Biological Therapy·Jakub SmolarDaniel Eberli
Dec 28, 2017·Investigative and Clinical Urology·Alan D Uren, Marcus J Drake
Jan 31, 2012·Urologia·Emilio Sacco
Oct 12, 2010·Nature Reviews. Urology·Dev M Gulur, Marcus J Drake
Aug 28, 2009·Current Urology Reports·Anne M Suskind, Phillip P Smith
Feb 13, 2018·Nature Reviews. Urology·Fatemeh AjalloueianMagdalena Fossum
Sep 5, 2020·Scandinavian Journal of Urology·Erik SagenRalph Peeker

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