PMID: 7541634Jun 1, 1995Paper

The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C

Neuron
B Varnum-FinneyL F Reichardt

Abstract

This paper identifies a neuronal receptor for tenascin-C (tenascin/cytotactin), an extracellular matrix protein that has previously been detected in developing sensory and motor neuron pathways and has been shown to regulate cell migration in the developing CNS. Antibodies specific for each subunit of the integrin alpha 8 beta 1 are used to demonstrate that alpha 8 beta 1 mediates neurite outgrowth of embryonic sensory and motor neurons on this extracellular matrix protein. In addition, expression of alpha 8 in K562 cells results in surface expression of alpha 8 beta 1 heterodimers that are shown to promote attachment of this cell line to tenascin. The major domain in tenascin that mediates neurite outgrowth is shown to be localized to fibronectin type III repeats 6-8.

References

Jan 1, 1991·Annual Review of Neuroscience·L F Reichardt, K J Tomaselli
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S S TanG M Edelman
May 6, 1988·Cell·R Chiquet-EhrismannM Chiquet
Dec 1, 1988·The Journal of Cell Biology·D R FriedlanderG M Edelman
Mar 1, 1989·The Journal of Cell Biology·M A Bourdon, E Ruoslahti
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C Lagenaur, V Lemmon
Jan 1, 1982·Methods in Enzymology·R TimplG R Martin
Apr 1, 1995·Molecular Biology of the Cell·U MüllerL F Reichardt
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A L PrietoK L Crossin

❮ Previous
Next ❯

Citations

Jun 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A ScholzeA Faissner
Mar 11, 2004·Journal of Molecular and Cellular Cardiology·Robert S Ross
Jun 24, 1998·Brain Research. Molecular Brain Research·J K PinkstaffC M Gall
Mar 14, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·A Joester, A Faissner
Jun 17, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·M SeiffertG Klein
Jun 12, 2003·Molecular and Cellular Neurosciences·Thomas BeckerCatherina G Becker
Dec 1, 1996·The Journal of Cell Biology·R BrandenbergerM Chiquet
Dec 31, 1997·Molecular Biology of the Cell·D FischerJ C Adams
Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
Jan 26, 2013·PloS One·Rajiv Sainath, Michael Granato
Oct 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhen HuangLouis F Reichardt
Nov 7, 2013·BioMed Research International·Stefan Plantman
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·T WilliamsonJ Taylor
Jul 16, 2014·Experimental Neurology·Andrew D Gaudet, Phillip G Popovich
Jan 12, 2012·Pharmacology & Therapeutics·Xin Wu, Doodipala Samba Reddy
Jun 23, 2011·Journal of Cellular and Molecular Medicine·Florence Brellier, Ruth Chiquet-Ehrismann
Jun 30, 2011·Developmental Neurobiology·Jonathan P MyersTimothy M Gomez
Jul 30, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Joanne E Murphy-Ullrich, E Helene Sage
Jun 10, 2015·The International Journal of Biochemistry & Cell Biology·Richard P Tucker, Ruth Chiquet-Ehrismann
Mar 1, 2012·Pharmacology & Therapeutics·Janette K Burgess, Markus Weckmann
Feb 23, 2000·Molecular Cell Biology Research Communications : MCBRC·D O Clegg
Feb 22, 2005·Biochemical and Biophysical Research Communications·Eduardo FariasLynn M Schnapp
Jun 15, 2000·The American Journal of Pathology·D LevineL M Schnapp
Jul 27, 2001·The Journal of Cell Biology·J H Miner
May 5, 1997·The Journal of Cell Biology·R A ClarkT A Springer
Oct 23, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A V LjubimovM C Kenney
Sep 23, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Teresa E WagnerLynn M Schnapp
Feb 16, 2018·Biological Reviews of the Cambridge Philosophical Society·Bart NieuwenhuisJames W Fawcett
Apr 22, 2015·Journal of the American Society of Nephrology : JASN·Michael J RandlesRachel Lennon
Sep 29, 2005·The Journal of Bone and Joint Surgery. British Volume·S Hall
Sep 2, 2016·The Open Neurology Journal·Caroline RanAndrea Carmine Belin
Feb 8, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Victoria L T BallardJay M Edelberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.