The inter-trial effects of stimulus and saccadic direction on prosaccades and antisaccades, in controls and schizophrenia patients.

Experimental Brain Research
Jason J S BartonDara S Manoach

Abstract

We investigated the influence of the direction of preceding saccadic trials on the latency of current prosaccades and antisaccades, in healthy subjects and patients with schizophrenia. When prosaccades and antisaccades were performed in separate, single-task blocks, we found that only prosaccades were delayed if the saccade in the prior trial was in the same direction, consistent with the expected directional effect from an 'inhibition of return'-like alternation advantage. However, both types of saccades were executed more quickly when the saccade in the penultimate trial was in the same direction, consistent with previous demonstrations of directional plasticity in monkeys. In blocks of randomly mixed prosaccades and antisaccades, the directional effects in healthy subjects were greatest when a prosaccade was preceded by an antisaccade, consistent with a summation of effects of alternation advantage (from the prior stimulus) and directional plasticity (from the prior saccade). Schizophrenic patients showed an additional phenomenon, a directionally specific inhibition of upcoming saccades by preceding antisaccades. These results suggest that saccades in humans are modulated by inter-trial effects attributable to both an 'inhib...Continue Reading

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Citations

Dec 1, 2006·Experimental Brain Research·Benjamin W Tatler, Samuel B Hutton
Jun 9, 2009·Experimental Brain Research·Cosima FrankeNorbert Kathmann
May 5, 2010·Experimental Brain Research·Mathias AbeggJason J S Barton
Nov 4, 2010·Experimental Brain Research·Bettina Olk, Yu Jin
Sep 6, 2012·Experimental Brain Research·Tara RastgardaniMathias Abegg
Apr 10, 2013·The Quarterly Journal of Experimental Psychology : QJEP·Claudia PeschkeBettina Olk
Feb 6, 2013·Biological Psychiatry·Dara S ManoachJason J S Barton
Aug 19, 2007·Biological Psychology·Cosima FrankeNorbert Kathmann
Oct 25, 2011·Biological Psychology·Mathias AbeggJason J S Barton
Apr 22, 2008·Current Biology : CB·Andrew J AndersonR H S Carpenter
Mar 15, 2015·Brain and Cognition·Katharine N ThakkarSohee Park
Jul 21, 2021·NeuroImage. Clinical·Matthew LehetKatharine N Thakkar

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