Oct 16, 2016

The Interaction Between Celiac Disease and Intestinal Microbiota

Journal of Clinical Gastroenterology
Giuseppe LosurdoAlfredo Di Leo

Abstract

Celiac disease (CD) is the most common autoimmune enteropathy, triggered by a deregulated immune response to gliadin. It has been hypothesized that human intestinal microbiota may interfere with the pathogenesis of the disease and in the clinical course of CD. In the present review, we analyzed the microbiota alterations observed in the course of CD, how they may influence the pathogenesis of CD, and the possible applications for a microbiota modulation in CD. In detail, most of the current literature underlined that the dysbiosis in CD is hallmarked by an increase in gram-negative and Bacteroidetes species, and by a decrease in Bifidobacteria and Lactobacilli. As the intestinal microbiota is able to modulate the cytokine environment, an unfavorable microbiota could amplify the immune response to gliadin in individuals with CD, whereas the administration of probiotic species could lead to a decrease in proinflammatory cytokine production. Therefore, dysbiosis could represent an important trigger in CD pathogenesis, along with genetic (HLA-haplotypes) and environmental factors (antibiotic administration, mode of delivery, and breastfeeding). Although data on the modulation of microbiota by GFD are conflicting, current evidence h...Continue Reading

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Citations

Mentioned in this Paper

Study
Immune Response
Pathogenic Aspects
Pathogenesis
Administration of Antibiotic
Mucositis
Environment
Gliadin
Administration Procedure
Autoimmune Enteropathy

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