The interaction between daughterless and sex-lethal in triploids: a lethal sex-transforming maternal effect linking sex determination and dosage compensation in Drosophila melanogaster

Developmental Biology
T W Cline

Abstract

Regulation of Drosophila sex determination and X-chromosome dosage compensation in response to the X-chromosome/autosome (X/A) balance of the zygote is shown to require proper functioning of both the da+ gene in the mother and the Sxl+ gene in the zygote. Previous studies led to the hypothesis that zygotic Sxl+ alleles are differentially active in females (XXAA) vs males (XYAA) in response to the X/A balance, and that maternal da+ gene product acts as a positive regulator in this connection. Sxl+ activity was proposed to impose the female developmental sequence on cells which would follow the male sequence in its absence. Important predictions of this proposal are verified. This study focuses primarily on the phenotype of triploid intersexes (XXAAA, X/A = 0.67). They are shown here to survive effects of da and Sxl mutations that would be lethal to diploids. The ambiguous X/A signal of intersexes normally causes them to develop as phenotypic mosaics of male and female tissue. Loss of maternal da+ or zygotic Sxl+ gene function shifts their somatic sexual phenotype to the male alternative. A gain-of-function mutation at Sxl has the opposite effect, imposing female development regardless of the maternal genotype with respect to da....Continue Reading

References

Oct 1, 1978·Genetical Research·T Marshall, J R Whittle
Apr 12, 1974·Nature·J C LucchesiG Maroni
Jun 1, 1980·International Journal of Radiation Oncology, Biology, Physics·F M KhanT H Kim
Sep 1, 1980·Genetics·J M Belote, J C Lucchesi
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R H DevlinT A Grigliatti
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J M Belote, B S Baker
Jan 1, 1980·Chromosoma·G Maroni, J C Lucchesi
Apr 1, 1957·The Journal of Experimental Zoology·A HANNAL-ALAVA, C STERN
Nov 1, 1925·Proceedings of the National Academy of Sciences of the United States of America·C B Bridges
Apr 1, 1946·Proceedings of the National Academy of Sciences of the United States of America·A H Sturtevant
Sep 1, 1978·Wilhelm Roux's Archives of Developmental Biology·Trudi SchüpbachRolf Nöthiger
Dec 1, 1977·Wilhelm Roux's Archives of Developmental Biology·Rolf NöthigerFelix Epper
Feb 1, 1980·Wilhelm Roux's Archives of Developmental Biology·Fritz-Helmut Ullerich

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Citations

Aug 18, 2010·Genetica·Jayendra Nath ShuklaJavaregowda Nagaraju
Nov 1, 1993·Trends in Genetics : TIG·T W Cline
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H S Chandra
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G L Waring, J C Pollack
Sep 11, 1995·Nucleic Acids Research·K HoshijimaY Shimura
Apr 16, 2004·The Plant Cell·Milos Tanurdzic, Jo Ann Banks
Jan 1, 1996·Annual Review of Genetics·T W Cline, B J Meyer
Feb 1, 1987·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Johannes HacksteinMonica Steinmann-Zwicky
Aug 1, 1991·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Begoña GranadinoLucas Sánchez
Aug 17, 1989·Nature·B S Baker
Jan 1, 1986·Developmental Genetics·R MannJ C Lucchesi
Jun 7, 2019·Genetics·Deborah J AndrewMichelle N Arbeitman
Aug 1, 1995·Molecular and Cellular Biology·G DeshpandeP Schedl
Mar 30, 2005·Genetics·Thomas W Cline

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