The interaction between high ammonia diet and bile duct ligation in developing rats: assessment by spatial memory and asymmetric dimethylarginine

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Li-Tung HuangYou-Lin Tain

Abstract

Bile duct ligation (BDL) in developing rats causes cholestasis, impaired liver function and cognition. Because both nitric oxide (NO) and ammonia are implicated in hepatic encephalopathy (HE), we hypothesized that asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, and ammonia affect cognition in young rats with BDL. Four groups of young male Sprague-Dawley rats ages 17 days were used: rat underwent laparotomy (SC group), rat underwent laparotomy plus a 30% ammonium acetate diet (SC+HA group), rat underwent BDL (BDL group), rats underwent BDL plus high ammonia diet (BDL+HA group). Spatial memory was assessed by Morris water maze task. Plasma was collected for biochemical and ADMA analyses. Liver and brain cortex were collected for determination of protein arginine methyltransferase-1 (PRMT1, ADMA-synthesizing enzyme) and dimethylarginine dimethylaminohydrolase (DDAH, ADMA-metabolizing enzyme). We found BDL group had significantly higher plasma direct/total bilirubin, aspartate aminotransferase, alanine aminotransferase, ADMA, liver p22(phox), and worse spatial performance as compared with SC group. High ammonia diet increased plasma ammonia and ADMA concentration, and aggravated spatial deficit in the prese...Continue Reading

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Citations

Mar 8, 2014·International Journal of Molecular Sciences·Jiunn-Ming SheenLi-Tung Huang
Nov 6, 2014·Advanced Biomedical Research·Nasrin HosseiniMaryam Radahmadi
Apr 18, 2013·Pediatrics and Neonatology·Kow-Aung ChangLi-Tung Huang
Mar 8, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·You-Lin Tain, Li-Tung Huang
Feb 5, 2013·European Journal of Pharmacology·Mohammad Reza ZarrindastMohammad Torabi Nami
Jun 7, 2015·Physiology & Behavior·M Méndez-LópezJ L Arias
Sep 21, 2013·Behavioural Brain Research·Nasrin HosseiniMohammad-Reza Zarrindast
Sep 25, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jiunn-Ming SheenLi-Tung Huang
May 27, 2020·International Journal of Geriatric Psychiatry·Deborah E MaldenRoy L Soiza
Jul 28, 2016·Canadian Journal of Physiology and Pharmacology·Michael A GilinskyRoman A Sukhovershin
Nov 26, 2016·Neurochemical Research·Anna CzarneckaMagdalena Zielińska
Feb 7, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Rafael Ochoa-SanchezChristopher F Rose
Jul 3, 2021·International Journal of Molecular Sciences·Yu-Chieh ChenLi-Tung Huang
Jul 15, 2020·Journal of Proteome Research·Anjana PathaniaRajat Sandhir

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