PMID: 2494987Feb 1, 1989Paper

The interaction between human blood-coagulation factor VIII and von Willebrand factor. Characterization of a high-affinity binding site on factor VIII

The Biochemical Journal
A LeyteK Mertens

Abstract

The interaction between human Factor VIII and immobilized multimeric von Willebrand Factor (vWF) was characterized. Equilibrium binding studies indicated the presence of multiple classes of Factor VIII-binding sites on vWF. The high-affinity binding (Kd = 2.1 x 10(-10) M) was restricted to only 1-2% of the vWF subunits. Competition studies with monoclonal antibodies with known epitopes demonstrated that the Factor VIII sequence Lys1673-Arg1689 is involved in the high-affinity interaction with vWF.

Citations

Oct 11, 1996·The Journal of Biological Chemistry·S W Pipe, R J Kaufman
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S W Pipe, R J Kaufman
Apr 23, 1999·The Journal of Biological Chemistry·A V BendetowiczG E Gilbert
Aug 14, 1999·The Journal of Biological Chemistry·P J LentingA J van Zonneveld
Apr 12, 2007·Journal of Thrombosis and Haemostasis : JTH·P J LentingC V Denis
May 29, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·V TerraubeP V Jenkins
Mar 29, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·L TangJ E Murphy
Aug 22, 2015·Blood·Sriram Krishnaswamy
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·R J Kaufman, S W Pipe
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·M JacqueminJ-M Saint-Remy
Feb 24, 2009·Blood·Rens de GrootJames T B Crawley
Oct 6, 2007·Blood·Ting-Chang HsuArthur R Thompson
Nov 18, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Md Imtaiyaz HassanFaizan Ahmad
Mar 18, 2015·Journal of Thrombosis and Haemostasis : JTH·B BoylanUNKNOWN Hemophilia Inhibitor Research Study Investigators
Feb 20, 2020·Journal of Thrombosis and Haemostasis : JTH·Judit RejtőIngrid Pabinger
Jun 9, 1995·The Journal of Biological Chemistry·E L Saenko, D Scandella
Oct 1, 1990·American Journal of Respiratory Cell and Molecular Biology·A E Chung, M E Durkin
Nov 6, 2008·Journal of Thrombosis and Haemostasis : JTH·S ButenasK G Mann
Feb 14, 1991·European Journal of Biochemistry·S KrishnanC Roitsch
Feb 12, 2019·Journal of Thrombosis and Haemostasis : JTH·Laura L SwystunDavid Lillicrap
Jan 1, 1991·Annals of the New York Academy of Sciences·D N Fass
Mar 12, 2021·Cellular and Molecular Gastroenterology and Hepatology·Tirthadipa Pradhan-SunddMargaret V Ragni
Feb 25, 2000·Thrombosis Research·M Spadafora-FerreiraJ Kalil

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.