The interaction between nanoscale surface features and mechanical loading and its effect on osteoblast-like cells behavior

Biomaterials
Ljupcho ProdanovX Frank Walboomers

Abstract

Osteoblasts respond to mechanical stimulation by changing morphology, gene expression and matrix mineralization. Introducing surface topography on biomaterials, independently of mechanical loading, has been reported to give similar effects. In the current study, using a nanotextured surface, and mechanical loading, we aimed to develop a multi-factorial model in which both parameters interact. Mechanical stimulation to osteoblast-like cells was applied by longitudinal stretch in parallel direction to the nanotexture (300 nm wide and 60 nm deep grooves), with frequency of 1 Hz and stretch magnitude varying from 1% to 8%. Scanning electron microscopy showed that osteoblast-like cells subjected to mechanical loading oriented perpendicularly to the stretch direction. When cultured on nanotextured surfaces, cells aligned parallel to the texture. However, the parallel cell direction to the nanotextured surface was lost and turned to perpendicular when parallel stretch to the nanotexture, greater than 3% was applied to the cells. This phenomenon could not be achieved when a texture with micro-sized dimensions was used. Moreover, a significant synergistic effect on upregulation of fibronectin and Cfba was observed when dual stimulation ...Continue Reading

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Citations

Jun 9, 2012·Annals of Biomedical Engineering·Nathan J CastroLijie Grace Zhang
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Aug 9, 2012·Tissue Engineering. Part a·Ljupcho ProdanovX Frank Walboomers
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Sep 4, 2012·Journal of Tissue Engineering and Regenerative Medicine·Ljupcho ProdanovX Frank Walboomers
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Feb 3, 2013·Biomaterials Science·Alexey KlymovX Frank Walboomers
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