The Interaction Between Neuroinflammation and β-Amyloid in Cognitive Decline in Parkinson's Disease

Molecular Neurobiology
Christine GhaderyAntonio P Strafella

Abstract

Activated microglia have been reported to play an important role in Parkinson's disease (PD). A more rapid cognitive decline has been associated with deposits of β-amyloid. In this study, the aim was to evaluate the role of brain β-amyloid and its relationship with activated microglia in PD patients with normal and impaired cognition. We studied 17 PD patients with normal cognition (PDn), 12 PD patients with mild cognitive impairment (PD-MCI), and 12 healthy controls (HCs) with [11C] Pittsburgh compound B (PIB) to assess the impact of β-amyloid deposition in the brain on microglial activation evaluated using the translocator protein 18-kDa (TSPO) radioligand [18F]-FEPPA. [11C] PIB distribution volume ratio was measured in cortical and subcortical regions. [18F]-FEPPA total distribution volume values were compared for each brain region between groups to evaluate the effect of PIB positivity while adjusting for the TSPO rs6971 polymorphism. Factorial analysis of variance revealed a significant main effect of PIB positivity in the frontal lobe (F(1, 34) = 7.1, p = 0.012). Besides the frontal (p = 0.006) and temporal lobe (p = 0.001), the striatum (p = 0.018), the precuneus (p = 0.019), and the dorsolateral prefrontal cortex (p = 0...Continue Reading

References

Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Jan 30, 2002·Bioorganic & Medicinal Chemistry Letters·Chester A MathisWilliam E Klunk
Jan 9, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Frank L MastagliaByron A Kakulas
Sep 27, 2005·Neurobiology of Disease·Alexander GerhardDavid J Brooks
Feb 21, 2006·Lancet Neurology·K Ray ChaudhuriUNKNOWN National Institute for Clinical Excellence
Jun 27, 2006·Psychiatry Research·Pablo RusjanShitij Kapur
Jul 26, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·P EdisonD J Brooks
Jan 25, 2011·Neuroscience Research·Lydia Alvarez-ErvitiMatthew J A Wood
Feb 1, 2011·Annals of Neurology·Victor L VillemagneChristopher C Rowe
Apr 28, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Pablo M RusjanRomina Mizrahi
Jan 26, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Irene LitvanMurat Emre
Apr 5, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Romina MizrahiSylvain Houle
Aug 10, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sonia LavisseCarole Escartin
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul EdisonDavid J Brooks
Feb 22, 2013·Parkinsonism & Related Disorders·Christopher KobyleckiAlexander Gerhard
Aug 13, 2013·The International Journal of Neuroscience·Zhiyou CaiLiang-Jun Yan
Nov 14, 2013·Acta Neuropathologica·Stefan ProkopFrank L Heppner
Sep 23, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Zhen FanPaul Edison
Apr 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Myria PetrouKirk A Frey
Jul 4, 2015·Brain : a Journal of Neurology·Aurelija JucaiteLars Farde
Mar 18, 2016·Brain : a Journal of Neurology·Lorraine HamelinUNKNOWN Clinical IMABio3 team

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Citations

Feb 23, 2020·Frontiers in Neurology·Sanskriti Sasikumar, Antonio P Strafella
Mar 10, 2020·The European Journal of Neuroscience·Romain TroubatVincent Camus
Nov 13, 2020·Frontiers in Neurology·Usman SaeedMario Masellis
Jan 28, 2021·Seminars in Nuclear Medicine·Aren van WaardeRudi A J O Dierckx
Apr 1, 2021·The International Journal of Neuroscience·Xin GuanYanqin Wang
Aug 14, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Fabien ChauveauHervé Boutin
Nov 2, 2021·Journal of Neurology·Peng-Fei Zhang, Fan Gao

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Methods Mentioned

BETA
Genotyping

Software Mentioned

SPSS Statistics
ROMI
PMOD

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