The interaction between noradrenaline and 5-hydroxytryptamine in the isolated perfused rat hindlimb

European Journal of Pharmacology
P B Wilton, T A McCalden


The vascular response to bolus injections of 5-hydroxytryptamine (5HT) over the range 0.01-10.0 microgram was measured in isolated perfused rat hindlimbs. The hindlimb vasculature displayed a vasoconstrictor response to 5HT, which was potentiated by the addition of 0.01 microgram/ml noradrenaline (NA) to the perfusate at all doses tested. The response to 5HT was also enhanced by the monoamine oxidase (MAO) inhibitor, tranylcypromine (0.05 mg/ml), suggesting that MAO located in the vascular wall is involved in the termination of the response to 5HT in the peripheral circulation. MAO inhibition abolishes the potentiation of 5HT by NA, indicating that this potentiation results from competition for MAO by both amines, leaving more amine intact to activate membrane receptors. Corticosterone (0.01 mg/ml), catecholamine extraneuronal uptake inhibitor, did not alter the response to 5HT, nor the increase of this response by NA, it thus appears that 5HT and NA have different membrane transport systems in the peripheral vasculature.


Oct 1, 1974·The Australian Journal of Experimental Biology and Medical Science·P R CarrollW E Glover
Oct 1, 1968·The Australian Journal of Experimental Biology and Medical Science·G C Scroop, J A Walsh
Aug 1, 1973·British Journal of Pharmacology·J F CoquilN H Neff
Jul 1, 1969·British Journal of Pharmacology·S Kalsner
Dec 1, 1966·British Journal of Pharmacology and Chemotherapy·I S De La LandeJ G Waterson

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Drug Interactions
Norepinephrine, (+, -)-Isomer
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Rats, Laboratory
In Vitro [Publication Type]

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