The interaction between propofol and clonidine for loss of consciousness

Anesthesia and Analgesia
Hideyuki HiguchiTetsuo Satoh

Abstract

Clonidine premedication reduces the intraoperative requirement for opioids and volatile anesthetics. Clonidine also reduces the induction dose of IV anesthetics. There is no information, however, regarding the effect of oral clonidine premedication on the propofol blood concentrations required for loss of consciousness, and the interaction between propofol and clonidine. We randomly administered target effect-site concentrations of propofol ranging from 0.5 to 5. 0 microg/mL by using computer-assisted target-controlled infusion to 3 groups of healthy male patients: Control (n = 35), 2.5 microg/kg Clonidine (n = 36), and 5.0 microg/kg Clonidine (n = 36) groups. Nothing was administered to the Control group. Clonidine (2.5 or 5.0 microg/kg) was administered orally 90 min before the induction of anesthesia in the Clonidine groups. After equilibration between the blood and effect-site for 15 min, a verbal command to open their eyes was given two times to the patients. Arterial blood samples for analysis of the serum propofol and clonidine concentrations were taken immediately before verbal commands were given. Measured serum propofol concentrations in equilibrium with the effect-site at which 50% of the patients did not respond to ...Continue Reading

References

Sep 1, 1992·British Journal of Anaesthesia·S McCluneR S Clarke
Feb 1, 1992·Journal of Pharmacokinetics and Biopharmaceutics·J R VarvelS L Shafer
Nov 1, 1991·British Journal of Anaesthesia·T G Short, P T Chui
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Sep 1, 1994·British Journal of Anaesthesia·T KatohK Ikeda
Jun 9, 1999·Anesthesiology·T W SchniderE J Youngs
Sep 18, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T GoyagiT Nishikawa
Jun 6, 2000·Anesthesiology·C F MintoS L Shafer
Oct 25, 2000·Anesthesiology·T Kamibayashi, M Maze

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Citations

Jul 18, 2008·Anesthesia and Analgesia·Jan F A HendrickxSteven L Shafer
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Duminda N WijeysunderaW Scott Beattie
Mar 7, 2018·The Cochrane Database of Systematic Reviews·Dallas DuncanDuminda N Wijeysundera
Aug 12, 2009·Revista brasileira de anestesiologia·Ricardo Francisco SimoniGuilherme Zemi

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