The interaction between pupil function and cardiovascular regulation in patients with acute schizophrenia

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Karl-Jürgen BärAndreas Voss

Abstract

Cardiac autonomic dysregulation has been reported in patients with schizophrenia. However, there are no definite data examining whether other branches of the autonomic nervous system are compromised as well and how they interrelate with cardiac function. In this study, we tested the hypothesis that the autonomic dysregulation at the heart is reflected in the regulation of the pupillary light reflex. We assessed heart rate variability and baroreflex sensitivity parameters as well as pupillographic measures in 28 unmedicated patients with schizophrenia and compared these measures to those of 28 controls. In addition, cardiovascular and pupillographic parameters were correlated in both groups. The obtained cardiovascular parameters indicated decreased parasympathetic modulation. Patients showed a significantly increased resting pupil diameter as well as reduced relative amplitude, suggesting a dominance of sympathetic control and a lack of parasympathetic modulation at the pupil. Intriguingly, the parasympathetic latency of the pupil constriction was similar in both groups and correlated with several cardiovascular parameters. These correlations were in the opposite direction in patients compared to controls. Furthermore, shorter ...Continue Reading

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Citations

Dec 19, 2012·Journal of Autism and Developmental Disorders·Chathuri DaluwatteGang Yao
Apr 16, 2009·Schizophrenia Bulletin·Karl-Jürgen BärHeinrich Sauer
Jun 1, 2013·Acta Neuropsychiatrica·Hsin-An ChangSan-Yuan Huang
May 7, 2013·European Archives of Psychiatry and Clinical Neuroscience·Masa IedaJun Horiguchi
Jan 23, 2016·Drug and Alcohol Dependence·Thomas JochumKarl-Jürgen Bär
Sep 17, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·A BirkhoferG Schmidt
Jul 27, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sandy BergerKarl-Jürgen Bär
Apr 29, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jae Seung ChangYong Min Ahn
Mar 30, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Takuji InagakiSeiichi Tsuji
Jan 20, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sandy BergerKarl-Jürgen Bär
Jul 16, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jeannine PeupelmannKarl-Jürgen Bär
May 2, 2009·Schizophrenia Research·Jeannine PeupelmannKarl-Jürgen Bär
May 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jae Seung ChangYong Sik Kim
Feb 7, 2009·Journal of the Neurological Sciences·Karl-Jürgen BärMichael Karl Boettger
May 21, 2014·Cranio : the Journal of Craniomandibular Practice·Annalisa MonacoDavide Pietropaoli
Sep 8, 2015·Journal of Psychiatric Research·Julian M MontaquilaJeffrey S Bedwell
Jul 3, 2009·Schizophrenia Research·Ripu D JindalVikram K Yeragani
May 1, 2013·Autonomic Neuroscience : Basic & Clinical·Andreas VossKarl-Jürgen Bär
Dec 23, 2016·Anaesthesia Critical Care & Pain Medicine·Céline RiffardDominique Chassard
Mar 14, 2018·Diagnostics·Charlotte A Hall, Robert P Chilcott
Feb 21, 2013·Journal of Clinical Psychopharmacology·Wei-Lieh HuangCheryl C H Yang
Mar 1, 2013·Clinical Schizophrenia & Related Psychoses·Hulegar A AbhishekhTalakad N Sathyaprabha
Mar 29, 2020·Frontiers in Neuroscience·Andy SchumannKarl Jürgen Bär
Sep 5, 2019·Postgraduate Medicine·Antonia KaltsatouGiorgos K Sakkas
Apr 29, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mine KarahanUğur Keklikçi
Jul 13, 2021·Schizophrenia Research·Brian J MillerWilliam V McCall

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