The interaction between sickle haemoglobin and the malarial parasite Plasmodium falciparum

Transactions of the Royal Society of Tropical Medicine and Hygiene
G Pasvol

Abstract

The mechanism whereby heterozygous carriers of the sickle cell gene are protected against fatal malarial infections due to Plasmodium falciparum has been examined in a short term in vitro cultivation system. The results have shown that both parasite invasion of red cells and parasite growth within red cells containing sickle haemoglobin (Hb-S) is restricted, but only under conditions of low (5%) oxygen tensions. To bring this about, the cells containing Hb-S need not sickle. Furthermore the growth retardation observed in the presence of Hb-S was also found to apply to the mature forms of the parasite. These findings offer a plausible mechanism for the protection of sickle heterozygotes against falciparum malaria.

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Citations

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Apr 9, 2004·Seminars in Hematology·Brian M CookeRoss L Coppel

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