PMID: 6991750Jan 1, 1980Paper

The interaction between the effects of insulin and ouabain on the activity of Na transport system in frog skeletal muscle

The Japanese Journal of Physiology
H KitasatoK Nishio

Abstract

The effects of insulin and ouabain on 22Na efflux and net Na loss were examined in frog sartorius muscles. After removal of ouabain, 22Na efflux which had been inhibited by ouabain remained at the inhibited level for more than 2 hr. In ouabain-free solution, insulin stimulated the Na efflux from ouabain-preincubated muscles. The stimulating effect of insulin on 22Na efflux was completely blocked by the presence of ouabain. Insulin shifted the Na efflux vs. intracellular Na concentration relationship toward the region of lower Na concentrations, and made the slope of log (Na efflux) vs. log [Na]1 relationship less step. On the other hand, ouabain shifted the Na efflux vs. intracellular Na concentration relationship toward the region of higher Na concentration, and made the slope of the log (Na efflux) vs. log [Na]1 relationship steeper. The relationship between insulin-stimulated Na efflux and intracellular Na concentration obtained from ouabain-preincubated muscle was located in the region of higher Na concentrations than that obtained from control muscle. These findings suggest that insulin increases an apparent affinity of binding sites for Na ions, and the possibility that insulin increases the Vmax of Na transport system ma...Continue Reading

Citations

Jan 1, 1990·Pflügers Archiv : European journal of physiology·Y Katayama
Jan 1, 1982·The Journal of Membrane Biology·R A Sjodin
Jan 1, 1987·Comparative Biochemistry and Physiology. A, Comparative Physiology·Y Marunaka
Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·Y Marunaka
Jan 1, 1983·Progress in Neurobiology·J J McArdle
Feb 1, 1985·The Journal of Clinical Investigation·J P KnochelN W Carter
Jan 1, 1989·Kidney International·T Clausen, M E Everts
Sep 1, 1982·Hypertension·E A Sims
Jan 1, 1981·Annals of the New York Academy of Sciences·D Erlij, H F Schoen
Mar 21, 1983·Biochimica Et Biophysica Acta·R D Moore
Jan 29, 1986·Biochemical and Biophysical Research Communications·M Kanbe, H Kitasato

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