The interaction between vigabatrin and diazepam on the electroencephalogram during active behaviour in rats: an isobolic analysis

European Journal of Pharmacology
Brigitte M BouwmanC M Van Rijn

Abstract

To test whether polytherapy with two gamma-aminobutyric acid (GABA) -ergic drugs might be clinically relevant for epilepsy treatment, effects on spike and wave discharges, the fraction of time spent being behaviourally active, and the background electroencephalogram (EEG) during behavioural activity of vigabatrin (15-500 mg/kg i.p.) and diazepam (1.25-10 mg/kg i.p.) were compared with their combination (dose ratio 1:25) in rats. Isobolic analyses were performed to describe the interactions. Unfortunately, no conclusions can be drawn concerning the interaction of both drugs on the spike and wave discharge activity because the effect of diazepam was shown to be dominant. Only vigabatrin decreased the behavioural activity, whereas there was a trend towards a decrease after diazepam. All treatments dose dependently increased the power in the beta frequency band. Unfortunately, the dose ratio was not optimal to describe the interaction. The theta peak frequency was dose dependently decreased after all treatments. There was a synergistic interaction between the two drugs on this variable. These data support both the idea that an increase in power in the beta frequency band can serve as a biomarker for GABAergic inhibition and the sug...Continue Reading

References

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Citations

Nov 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jarogniew J LuszczkiStanislaw J Czuczwar
Dec 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ivan PavlovAlexey Semyanov
Nov 26, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Karine Sarkisova, Gilles van Luijtelaar
Jul 24, 2007·Epilepsy Research·Brigitte M BouwmanClementina M van Rijn
Sep 24, 2004·Epilepsy & Behavior : E&B·Inna S MidzyanovskayaGilles van Luijtelaar
Nov 8, 2013·Journal of Neurophysiology·Giorgio La CorteSteven J Schiff
Mar 28, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M-T DanglesM Eisermann

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