The interaction of a type A retroviral particle and class II human leukocyte antigen susceptibility genes in the pathogenesis of Graves' disease

The Journal of Clinical Endocrinology and Metabolism
J B JaspanM Bryer-Ash

Abstract

We have previously reported that over 85% of patients with Graves' disease have detectable serum antibodies against a human intracisternal type A retroviral particle (HIAP), which are not present in age- and gender-matched controls, suggesting a role for HIAP in triggering the autoimmune process leading to Graves' disease. To investigate the interaction of this viral particle with genetic factors, 35 members of 3 kindreds, selected because of a high family prevalence of Graves' disease (a total of 11 members affected), were examined for clinical signs of thyroid dysfunction, goiter, and opthalmopathy. Thyroid function tests and autoimmune serological profiles were also obtained. In addition, subjects were tested for the presence of antibodies against HIAP by means of immunoblot analysis of their sera, and their human leukocyte antigen (HLA) class II alleles were determined by DNA methodology. Molecular genetic analyses enabled the detection of postulated HLA susceptibility haplotypes in each family. These families had 8, 4, and 5 members, respectively, with such apparent susceptibility genes and 11, 5, and 9 members, respectively, with immunological evidence of retroviral exposure. In the presence of both factors (codetected in...Continue Reading

Citations

Jan 1, 2005·Indian Journal of Clinical Biochemistry : IJCB·Manorama SwainBinoy Kumar Mohanty
Jan 14, 2009·Virology Journal·Rachel Desailloud, Didier Hober
Mar 25, 2009·Journal of Autoimmunity·Yaron Tomer, Amanda Huber
Mar 20, 2004·Clinical and Experimental Immunology·M J Simmonds, S C L Gough
Apr 19, 1997·Lancet·M P Everson, W D Blackburn
Dec 22, 2009·Journal of Autoimmunity·Yaron Tomer
Aug 4, 2005·The Journal of Clinical Endocrinology and Metabolism·Takehiro MatsudaNaoki Mori

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