The interaction of actinide and lanthanide ions with hemoglobin and its relevance to human and environmental toxicology

Journal of Hazardous Materials
Amit KumarBadri N Pandey

Abstract

Due to increasing use of lanthanides/actinides in nuclear and civil applications, understanding the impact of these metal ions on human health and environment is a growing concern. Hemoglobin (Hb), which occurs in all the kingdom of living organism, is the most abundant protein in human blood. In present study, effect of lanthanides and actinides [thorium: Th(IV), uranium: U(VI), lanthanum: La(III), cerium: Ce(III) and (IV)] on the structure and function of Hb has been investigated. Results showed that these metal ions, except Ce(IV) interacted with carbonyl and amide groups of Hb, which resulted in the loss of its alpha-helix conformation. However, beyond 75μM, these ions affected heme moiety. Metal-heme interaction was found to affect oxygen-binding of Hb, which seems to be governed by their closeness with the charge-to-ionic-radius ratio of iron(III). Consistently, Ce(IV) being closest to iron(III), exhibited a greater effect on heme. Binding constant and binding stoichiometry of Th(IV) were higher than that of U(VI). Experiments using aquatic midge Chironomus (possessing human homologous Hb) and human blood, further validated metal-Hb interaction and associated toxicity. Thus, present study provides a biochemical basis to u...Continue Reading

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Citations

Mar 8, 2018·Journal of Molecular Recognition : JMR·Hua-Xin ZhangQing-Hua Xia
Jun 27, 2019·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Arjun SharmaManoj Kumbhakar
Aug 17, 2019·Physical Chemistry Chemical Physics : PCCP·Björn DrobotSatoru Tsushima
Aug 13, 2017·Journal of Inorganic Biochemistry·Claudia WilkeAtsushi Ikeda-Ohno
Sep 13, 2018·Chemical Research in Toxicology·Astrid BarkleitAtsushi Ikeda-Ohno
Nov 4, 2021·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Zhenxing ChiXunuo Zhang

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