PMID: 8948501Aug 1, 1996Paper

The interaction of agouti signal protein and melanocyte stimulating hormone to regulate melanin formation in mammals

Pigment Cell Research
M FurumuraVincent J Hearing

Abstract

Important regulatory controls of melanogenesis that operate at the subcellular level to modulate the structural and/or the functional nature of the melanins and melanin granules produced in melanocytes are reviewed. Melanocyte stimulating hormone and agouti signal protein have antagonistic roles and possibly opposing mechanisms of action in the melanocyte. In the mouse, melanocyte stimulating hormone promotes melanogenic enzyme function and elicits increases in the amount of eumelanins produced, while agouti signal protein reduces total melanin production and elicits the synthesis of pheomelanin rather than eumelanin. We are now beginning to understand the complex controls involved in regulating this switch at the molecular and biochemical levels. The quality and quantity of melanins produced by melanocytes have important physiological consequences for melanocyte function and undoubtedly play important roles in the various functions of the melanins per se, including hair and skin coloration and photoprotection.

References

Jan 1, 1976·Endeavour·G Prota, R H Thomson
Dec 24, 1992·Cell·S J BultmanR P Woychik
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Z Wang, D D Brown
Jan 15, 1992·Experientia·A SlominskiJ Mazurkiewicz
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B S KwonK K Kim
Mar 29, 1991·Biochemical and Biophysical Research Communications·N BirchallJ Pawelek
Jan 1, 1987·Methods in Enzymology·T D Sargent
Aug 1, 1983·The Journal of Cell Biology·R HalabanA B Lerner
Nov 1, 1983·Peptides·A J ThodyS Shuster
Jul 1, 1980·The Journal of Investigative Dermatology·G Prota
Jan 1, 1994·Advances in Human Genetics·R A Spritz, V J Hearing
Apr 1, 1995·Current Opinion in Immunology·P Liang, A B Pardee
Sep 1, 1995·The Journal of Investigative Dermatology·H OzekiT Hirobe
Feb 1, 1995·Human Molecular Genetics·B D WilsonG S Barsh
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·J ManneL D Siracusa
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·M B ZemelW O Wilkison
Feb 15, 1995·European Journal of Pharmacology·H B SchiöthV Chhajlani
Aug 1, 1994·Pigment Cell Research·G HuntA J Thody
Dec 1, 1994·Trends in Genetics : TIG·L D Siracusa
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z Abdel-MalekV J Hearing
Oct 1, 1994·Pigment Cell Research·J L BologniaJ M Pawelek

❮ Previous
Next ❯

Citations

Sep 17, 2008·Biochemical Genetics·Chun-Juan TangJing-Fen Keng
Oct 3, 1998·Experimental Dermatology·K SchallreuterB A Gilchrest
Feb 1, 1997·Pigment Cell Research·R R BowersO Chavez
Dec 30, 1999·Pigment Cell Research·Y M ParsonsD W Cooper
Jan 23, 2004·PLoS Biology·Sophie I CandilleGregory S Barsh
Aug 1, 2010·Epigenomics·Cheryl Chui Ying LiCatherine M Suter
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·M FurumuraV J Hearing
Aug 10, 2007·The Journal of Investigative Dermatology·Hidenori WatabeVincent J Hearing
Apr 23, 2009·International Journal of Cancer. Journal International Du Cancer·Hongmei NanJiali Han
Mar 29, 2003·Veterinary Dermatology·Shola S Sulaimon, Barbara E Kitchell
May 20, 2003·Pigment Cell Research·Tsuneto KushimotoVincent J Hearing
May 23, 2008·International Journal of Cosmetic Science·L Petit, G E Piérard
Dec 28, 2004·Journal of Dermatological Science·Vincent J Hearing
Aug 15, 1998·Biochemical and Biophysical Research Communications·S B Potterf, V J Hearing
Feb 22, 2001·Experimental Eye Research·P SamaraweeraS J Orlow
Aug 16, 2000·Experimental Cell Research·V M ViradorV J Hearing
Aug 20, 2014·Frontiers in Behavioral Neuroscience·Valeria CarolaCornelius T Gross
Mar 15, 2006·Anais Da Academia Brasileira De Ciências·Carolina R CamargoAna Maria L Castrucci
Feb 23, 2007·Nature·Jennifer Y Lin, David E Fisher
Jan 15, 1998·Pigment Cell Research·T FukuzawaM Nishioka
Jan 6, 2001·Molecular Endocrinology·W A NijenhuisR A Adan
May 19, 2000·Annals of the New York Academy of Sciences·S Solomon
Apr 16, 2020·Journal of Animal Science and Technology·Olanrewaju B MorenikejiIkhide G Imumorin
May 11, 2021·Animal Genetics·H BeauvoisM Abitbol
May 13, 2021·Ecology and Evolution·Rachel A MundsGregory E Blomquist

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
M FurumuraVincent J Hearing
Genetics, Selection, Evolution : GSE
J KantanenS Adalsteinsson
© 2021 Meta ULC. All rights reserved