PMID: 6982708Aug 1, 1982Paper

The interaction of anthraquinone dyes with the plasmid-mediated OXA-2 beta-lactamase

The Biochemical Journal
C MonaghanJ W Dale

Abstract

Although beta-lactamases do not require any nucleotide co-substrates, the OXA-2 type is inhibited competitively by Cibacron Blue 3GA, and by other anthraquinone dyes, including some simpler compounds with no side chain. The enzyme causes a red shift in the spectrum of Cibacron Blue. The beta-lactamase can be adsorbed in Blue Sepharose and specifically eluted by benzylpenicillin. These results indicate that the binding of anthraquinone dyes is a specific effect similar to that seen with many nucleotide-binding enzymes.

Citations

Apr 26, 2016·Medicinal Research Reviews·Enas M Malik, Christa E Müller
Sep 29, 2005·Antimicrobial Agents and Chemotherapy·S A AdediranR F Pratt
Mar 1, 1996·The International Journal of Biochemistry & Cell Biology·T KvernmoJ S McKinley-McKee
Jan 4, 1988·Biochimica Et Biophysica Acta·N S Samuelov, N Citri
Aug 16, 2008·Biochemistry·S A Adediran, R F Pratt
May 1, 1987·Antimicrobial Agents and Chemotherapy·M BoissinotR C Levesque
Mar 18, 2017·Journal of Medicinal Chemistry·Muhammad RafehiYounis Baqi
Dec 8, 2005·Biochemistry·Sudipta MajumdarR F Pratt

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