The interaction of anticancer therapies with tumor-associated macrophages

The Journal of Experimental Medicine
Alberto Mantovani, Paola Allavena

Abstract

Macrophages are essential components of the inflammatory microenvironment of tumors. Conventional treatment modalities (chemotherapy and radiotherapy), targeted drugs, antiangiogenic agents, and immunotherapy, including checkpoint blockade, all profoundly influence or depend on the function of tumor-associated macrophages (TAMs). Chemotherapy and radiotherapy can have dual influences on TAMs in that a misdirected macrophage-orchestrated tissue repair response can result in chemoresistance, but in other circumstances, TAMs are essential for effective therapy. A better understanding of the interaction of anticancer therapies with innate immunity, and TAMs in particular, may pave the way to better patient selection and innovative combinations of conventional approaches with immunotherapy.

References

Jul 1, 1992·Immunology Today·A MantovaniL Ruco
Apr 22, 1992·International Journal of Cancer. Journal International Du Cancer·N ColomboP Allavena
Feb 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E Pujade-LauraineM Brandely
Apr 12, 2006·The Journal of Experimental Medicine·Ilona KryczekWeiping Zou
Apr 19, 2006·Cancer Research·Patrick PaulusSeyedhossein Aharinejad
May 21, 2008·The Journal of Experimental Medicine·Thorsten HagemannFrances R Balkwill
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Feb 20, 2010·The American Journal of Pathology·Seth B CoffeltMichele De Palma
Jun 25, 2010·Nature Reviews. Cancer·Alicia S ChungNapoleone Ferrara
Sep 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cathy C ZhangTodd VanArsdale
Sep 22, 2010·Nature Immunology·Subhra K Biswas, Alberto Mantovani
Dec 17, 2010·Journal of Mammary Gland Biology and Neoplasia·Stephen L Shiao, Lisa M Coussens
Jan 18, 2011·Nature Immunology·Thomas KrausgruberIrina A Udalova
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Masahisa JinushiHideaki Tahara
Dec 14, 2011·Genes & Development·Tanaya ShreeJohanna A Joyce
Jan 27, 2012·Trends in Immunology·Brian RuffellLisa M Coussens
Mar 2, 2012·The Journal of Clinical Investigation·Antonio Sica, Alberto Mantovani
Mar 9, 2012·The New England Journal of Medicine·Michael A PostowJedd D Wolchok
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Mar 23, 2012·Nature Reviews. Immunology·Dmitry I GabrilovichVincenzo Bronte
Oct 26, 2012·The Journal of Pathology·Alberto MantovaniMassimo Locati
Nov 20, 2012·Annual Review of Immunology·Guido KroemerLaurence Zitvogel
Jan 19, 2013·Science·Lisa M CoussensA Karolina Palucka
Jan 22, 2013·Cell·Renato OstuniGioacchino Natoli
Feb 16, 2013·Cancer Cell·Giovanni GermanoPaola Allavena
Feb 21, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Martin Franz SprinzlUlrike Protzer
Mar 23, 2013·Cancer Cell·Michele De Palma, Claire E Lewis
Apr 27, 2013·Nature·Thomas A WynnJeffrey W Pollard

❮ Previous
Next ❯

Citations

Jun 23, 2015·Expert Review of Anticancer Therapy·Charles PottierPascale Quatresooz
Oct 11, 2015·Journal of Drug Targeting·Fernando Torres Andón, María José Alonso
Aug 13, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·W HuC Wu
Feb 14, 2016·Seminars in Immunology·Ainhoa ArinaVincenzo Bronte
Feb 20, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Armando RojasIleana Gonzalez
Feb 5, 2016·Cancer Letters·Ting Wu, Yun Dai
Jun 15, 2015·Biochimica Et Biophysica Acta·Anna JohanssonRuth Ganss
Mar 8, 2016·Trends in Cancer·Ruth A Franklin, Ming O Li
Jan 29, 2016·Japanese Journal of Clinical Oncology·Susumu SuzukiRyuzo Ueda
Dec 29, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Kunal BhattacharyaBengt Fadeel
Oct 2, 2015·Current Opinion in Pharmacology·Joachim L Schultze
Jan 11, 2016·Journal of Internal Medicine·S MuenstS Hoeller
Mar 10, 2016·Cellular and Molecular Life Sciences : CMLS·Cristina BelgiovineRoberta Frapolli
Mar 12, 2016·Nature Reviews. Cancer·Sjoerd H van der BurgCornelis J M Melief
Feb 5, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Arantza AzpilikuetaIgnacio Melero
Jul 27, 2015·Cellular and Molecular Life Sciences : CMLS·Antonio SicaChiara Porta
Nov 13, 2015·Seminars in Immunology·Chiara PortaAntonio Sica
Apr 5, 2016·Proceedings of the National Academy of Sciences of the United States of America·Teresa E PetersonRakesh K Jain
Apr 5, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jonas KloepperRakesh K Jain
May 4, 2016·Oncoimmunology·Giovanni Francesco CastinoFederica Marchesi
Jul 1, 2015·Nature Reviews. Clinical Oncology·Dörthe Schaue, William H McBride
Mar 5, 2016·International Journal of Cancer. Journal International Du Cancer·Maria Rosaria GaldieroSébastien Jaillon
May 18, 2016·Biochemical and Biophysical Research Communications·Jing LiLisa X Xu
May 24, 2016·Immunology Letters·Hana Totary-JainRuth Gallily
Jul 23, 2016·Pathology International·Motohiro Takeya, Yoshihiro Komohara
Oct 25, 2016·Cell Metabolism·Mathias WenesMassimiliano Mazzone
Jan 14, 2017·Molecular Oncology·Daniele V F TaurielloEduard Batlle
Apr 13, 2017·Cancer Immunology, Immunotherapy : CII·Antonio SicaAnna Pastò
Feb 16, 2017·Journal of Cellular Physiology·Rana Jahanban-EsfahlanBahman Yousefi

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
antisense oligonucleotides
transgenic
biopsies

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Related Papers

Current Opinion in Pharmacology
Alberto MantovaniPaola Allavena
Nihon rinsho. Japanese journal of clinical medicine
Hiroyuki Osada, Hideaki Kakeya
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Zhang Yin-XuZhang Jun Hua
[Rinshō ketsueki] The Japanese journal of clinical hematology
Masahisa Jinushi
© 2022 Meta ULC. All rights reserved