The interaction of cytokines with human basophils and mast cells

International Archives of Allergy and Immunology
J T SchroederL M Lichtenstein

Abstract

Human mast cells and basophils participate in allergic inflammation by releasing preformed and newly synthesized mediators upon cross-linking of cell surface IgE/receptor complexes with specific antigen. It is becoming increasingly apparent, however, that the basophil response is up-regulated by a far greater number of cytokines than is the mast cell, making the basophil more sensitive to products that are commonly generated during immune reactions. As a result, basophils may have a greater role in the chronic allergic inflammation that characterizes diseases such as asthma. This belief is supported further by the fact that the basophil has recently been shown to generate interleukin-4, and possibly other cytokines, indicating a role for this cell in directing the immune response of other cell participating in allergic lesions.

Citations

Dec 1, 1996·Current Opinion in Immunology·S M MacDonald
Jul 4, 2012·BMC Pediatrics·Asimenia AngelidouTheoharis C Theoharides
Jun 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W J LieJ S Van Der Zee

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