PMID: 9630036Jun 18, 1998Paper

The interaction of glomerular mesangial cells and epithelial cells

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
D WangP L Wang

Abstract

The interaction of cells within the glomerulus plays an important role in the development and progression of glomerular disease. To investigate the interaction of glomerular mesangial cells (GMC) and epithelial cells (GEC), and mediator(s) of this interaction, we investigated the effect of Adriamycin (doxorubicin hydrochloride)-induced (ADR) rat GMC-conditioned medium (GMC-CM) on the incorporation of 35S, 3H-leucine, and 3H-thymidine in normal rat GEC, as well as 3H-thymidine uptake by normal rat GMC in response to ADR-rat GEC-CM. In addition, changes in the responsiveness to interleukin-6 (IL-6) and the products of IL-6 were assessed in ADR-rat GMC. The results showed that: (1) GMC-CM of ADR-rat with heavy proteinuria stimulated GEC proliferation and the synthesis of sulfated compounds and protein, while the GEC-CM of ADR-rat from the same nephrotic period increased GMC proliferation; (2) the ADR-rat GMC had altered responsiveness to IL-6 and its products. The stimulation index results demonstrated the interaction of GMC and GEC in the ADR-induced rat model, and that this interaction related closely to the degree of proteinuria and was mediated by soluble products of the damaged glomerular cell.

Citations

Jul 18, 2008·Journal of the American Society of Nephrology : JASN·Shirong ZhengPaul N Epstein
Jul 7, 2005·American Journal of Physiology. Renal Physiology·Adrian NanezKenneth S Ramos
Apr 29, 2004·American Journal of Physiology. Renal Physiology·Jong-Shiaw JinAnn Chen

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